LDK may refer to:
- Ceritinib or LDK378, a drug used for the treatment non-small cell lung cancer
- L.D.K. Lounge Designers Killer, a 2005 album by Japanese band Capsule.
- LDK, an abbreviation for Living room, Dining room, Kitchen for housing options in Japan.
- L DK, a romantic comedy manga series by Ayu Watanabe.
- LDK Solar Co, a Chinese company that manufactures crystalline solar wafers
- Campus Dakwah Institute (Lembaga Dakwah Kampus), a term for Islamic student organization in Indonesia
- Democratic League of Kosovo (Lidhja Demokratike e Kosovës), a political party in Kosovo
- Lidköping-Hovby Airport, IATA airport code
- Grand Duchy of Lithuania (Lietuvos Didžioji Kunigaikštystė), a medieval state in Eastern Europe
- Lycée de Kigali, a secondary school in Kigali, Rwanda