LKM or lkm may refer to:
- 7, Lok Kalyan Marg, the official residence and principal workplace of the Prime Minister of India
- "Liver Kidney Microsomal", the target of an Anti-LKM antibody
- LKM Unia Leszno, a Polish motorcycle racing team
- Loadable kernel module, an object code file used to extend the kernel of a computer's operating system
- Lokomotivbau Karl Marx, a factory complex in East Germany, formerly owned by Orenstein & Koppel