LGSN

Lengsin is a protein that in humans is encoded by the LGSN gene.

LGSN
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2J9I
Identifiers
Aliases	LGSN, GLULD1, LGS, lengsin, lens protein with glutamine synthetase domain
External IDs	OMIM: 611470; MGI: 2672844; HomoloGene: 9569; GeneCards: LGSN; OMA:LGSN - orthologs
Gene location (Human) Chr. Chromosome 6 (human) Band 6q12 Start 63,275,951 bp End 63,319,983 bp
Gene location (Mouse) Chr. Chromosome 1 (mouse) Band 1|1 B Start 31,215,482 bp End 31,243,806 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in buccal mucosa cell testicle gonad right lobe of liver placenta epithelium of bronchus bronchial epithelial cell human kidney kidney tubule islet of Langerhans Top expressed in lens embryo spermatocyte spermatid neural layer of retina More reference expression data BioGPS n/a
Gene ontology Molecular function catalytic activity glutamate-ammonia ligase activity Cellular component plasma membrane membrane Biological process glutamine biosynthetic process nitrogen compound metabolic process nitrogen utilization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51557 266744 Ensembl ENSG00000146166 ENSMUSG00000050217 UniProt Q5TDP6 Q8CIX8 RefSeq (mRNA) NM_001143940 NM_016571 NM_153601 RefSeq (protein) NP_001137412 NP_057655 NP_705829 Location (UCSC) Chr 6: 63.28 – 63.32 Mb Chr 1: 31.22 – 31.24 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Lengsin is a survivor of an ancient family of class I glutamine synthetases in eukaryotes that has undergone evolutionary re-engineering for a tissue-specific, noncatalytic role in the lens of the vertebrate eye. Lengsin is the result of the recruitment of an ancient enzyme may act as a component of the cytoskeleton or as a chaperone for the reorganization of intermediate filament proteins during terminal differentiation in the lens. It does not seem to have enzymatic activity.

Further reading

• Wyatt K, White HE, Wang L, Bateman OA, Slingsby C, Orlova EV, Wistow G (December 2006). "Lengsin is a survivor of an ancient family of class I glutamine synthetases re-engineered by evolution for a role in the vertebrate lens". Structure. 14 (12). London, England: 1823–34. doi:10.1016/j.str.2006.10.008. PMC 1868402. PMID 17161372.

External links

• "Q5TDP6 (LGSN_HUMAN)". UniProtKB.