Lewis Clark (1923–2003) was a Canadian politician.
Lewis Clark or Lewis Clarke may also refer to:
- Lewis Gaylord Clark (1808–1873), American magazine editor and publisher
- Lewis Clarke (c. 1812–1897), American former slave, author, and lecturer
- Lewis Whitehouse Clark (1828–1900), American judge
- Lewis Clarke (priest), Archdeacon of Llandaff, Wales, from 1977 to 1988
- Lewis J. Clarke (1927–2021), English-American landscape architect