These are the songs that reached number one on the Top 50 Best Sellers chart in 1953 as published by Cash Box magazine.
| Issue date | Song | Artist |
|---|---|---|
| January 3 | "I Saw Mommy Kissing Santa Claus" | Jimmy Boyd |
| January 10 | "Why Don't You Believe Me" | Joni James |
| January 17 | "Don't Let The Stars Get In Your Eyes" | Perry Como |
| January 24 | ||
| January 31 | ||
| February 7 | "Till I Waltz Again with You" | Teresa Brewer |
| February 14 | ||
| February 21 | ||
| February 28 | ||
| March 7 | ||
| March 14 | ||
| March 21 | "The Doggie in the Window" | Patti Page |
| March 28 | ||
| April 4 | ||
| April 11 | ||
| April 18 | ||
| April 25 | ||
| May 2 | ||
| May 9 | "The Song from Moulin Rouge" | Percy Faith & Orchestra |
| May 16 | ||
| May 23 | ||
| May 30 | ||
| June 6 | ||
| June 13 | ||
| June 20 | ||
| June 27 | ||
| July 4 | "I'm Walking Behind You" | Eddie Fisher |
| July 11 | ||
| July 18 | ||
| July 25 | ||
| August 1 | ||
| August 8 | ||
| August 15 | "No Other Love" | Perry Como |
| August 22 | "Vaya con Dios (May God Be With You)" | Les Paul and Mary Ford |
| August 29 | ||
| September 5 | "Crying in the Chapel" | June Valli |
| September 12 | "Vaya con Dios (May God Be With You)" | Les Paul and Mary Ford |
| September 19 | "Crying in the Chapel" | June Valli, Darrell Glenn, Rex Allen, The Orioles |
| September 26 | ||
| October 3 | "You, You, You" | The Ames Brothers |
| October 10 | "Vaya con Dios (May God Be With You)" | Les Paul and Mary Ford |
| October 17 | ||
| October 24 | "St. George and the Dragonet" | Stan Freberg |
| October 31 | ||
| November 7 | ||
| November 14 | "Rags to Riches" | Tony Bennett |
| November 21 | "Eh, Cumpari" | Julius La Rosa |
| November 28 | "Rags to Riches" | Tony Bennett |
| December 5 | ||
| December 12 | ||
| December 19 | ||
| December 26 | "Oh My Pa-Pa (O Mein Papa)" | Eddie Fisher, Eddie Calvert |