- Maria Abashova, ballet dancer
- Roman Abraham, general of the Polish army
- Pavlo Arie, screenwriter and playwright
- Kazimierz Ajdukiewicz, logician and philosopher
- Spirydion Albański, football goalkeeper of the Poland National Team
- Zofia Albinowska-Minkiewiczowa, painter
- Stanislaw Albinowski, economist, columnist and journalist
- Bohdan Ihor Antonych, poet
- Stefan Askenase (1896–1985), pianist
- Szymon Askenazy, historian and politician, founder of the Lwów-Warsaw historical school
- Muhammad Asad, translator of Quran into English (born in Lemberg as Leopold Weiss)
- Herman Auerbach, mathematician
- Emanuel Ax, American pianist
- Teodor Axentowicz, painter
- Erwin Axer, actor and theatre professor
- Oswald Balzer, law historian, rector of the Lwów University (1895–1896), founder of the Society for Support of Polish Science in Lwów (Tow. dla Popierania Nauki Pol. we Lwowie), the first scientific organisation in the city
- Stefan Banach, mathematician
- Yuri Bashmet, viola soloist
- Kazimierz Bartel, mathematician and politician, prime minister of Poland (1926–1930)
- Adolf Beck (1863–1942), physiologist
- Joseph Beer (1908–1987), composer
- Alexander Beliavsky, chess grandmaster
- Józef Bem, Polish and Hungarian national hero
- Saint Józef Bilczewski, Archbishop of Lviv and a Catholic saint
- Szymon Okolski (1580–1653), a historian, specialist in heraldry, provincial of the Dominican Order
- Fabian Birkowski, writer, preacher
- Wojciech Bobowski (1610–1675), dragoman and musician in the Ottoman Empire, translated the Bible into Ottoman Turkish
- Wojciech Bogusławski, composer
- Tadeusz Bór-Komorowski, general of the Polish army, commander-in-chief of the Home Army
- Mieczysław Boruta-Spiechowicz, general of the Polish army
- Naftali Botwin, political militant and labor activist
- Michał Boym (ca. 1612–1659), Jesuit missionary in China, known for his travels and writings
- Heinrich Gottfried von Bretschneider, German satirical writer
- Julia Brystiger, political militant, member of the security apparatus of the Polish People's Republic
- Jan Brzoza, writer, publicist
- Martin Buber, philosopher
- Solomon Buber, banker and philosopher
- Mieczysław Gębarowicz, scientist and art historian, director of the Ossolineum Institute during World War II
- Eugeniusz Geppert, painter
- Franciszek Ksawery Godebski, director of the Ossolineum and father to Cyprian Godebski, renowned sculptor
- Julian Godlewski, businessman and philanthropist
- Maksymilian Goldstein, a pre-war Judaica collector, director of the Lviv Jewish Museum, and owner of a privately-maintained museum
- Georgiy R. Gongadze, journalist kidnapped and murdered in 2000
- Zygmunt Gorgolewski, architect, constructor of the Grand Theatre in Lwów (currently the Lviv Theatre of Opera and Ballet)
- Kazimierz Górski, football coach
- Uri Zvi Greenberg, poet
- Artur Grottger, late romanticist painter
- Stanisław Kaczor-Batowski, painter
- Bertha Kalich, actress
- Vera Kamsha, fantasy writer
- Michał Karaszewicz-Tokarzewski, general
- Stanisław Kasznica, resistance soldier
- Wojciech Kilar, composer
- Lubka Kolessa, pianist
- Yevhen Konovalets, Ukrainian nationalist leader
- Maria Konopnicka, writer
- Ihor Kobrin, film director
- Juliusz Kossak, painter
- Ihor Kozhan, Ukrainian archivist, cultural and public figure
- Jan Krukowiecki, general
- Solomiya Krushelnytska, opera singer
- Tadeusz Krwawicz, ophthalmologist
- Jerzy Kulczycki, civil engineer and activist publisher and bookseller
- Jacek Kuroń, freedom fighter and politician (Solidarity, KOR)
- Vilém Kurz, pianist, professor at the Lwów State Conservatory
- Ilona Kurzowa, pianist
- Wacław Kuchar, talented athlete, multiple champion of Poland in various sports
- Stanisław Jerzy Lec, poet and aphorist
- Stanisław Lem, science fiction writer and futurist
- Stanisław Leśniewski, philosopher and logician
- Stanisław I Leszczyński (1677–1766), twice King of Poland.[1]
- Antoni Łomnicki, mathematician
- Roman Longschamps de Berier, lawyer, last rector of the Jan Kazimierz University
- Alfred J. Lotka, mathematician, physical chemist, statistician, biophysicist, author of predator-prey model
- Yuriy Loutseiko, guitarist in Smerichka and Vatra
- Ignacy Łukasiewicz, engineer, pioneer of oil industry
- Jan Łukasiewicz, philosopher and logician
- Oleh Luzhnyi, former professional footballer
- Stanisław Maczek, Polish World War II general, Commander Allied (Polish) 1st Armoured Division in Western Europe
- Kornel Makuszyński, writer of books for children
- Michael Malice, Author, political commentator, Anarchist
- Alexandra Marinina, Russian writer of detective stories
- Leopold von Sacher-Masoch, writer, author of Venus in Furs
- Kazimierz Michałowski, Egyptologist, founder of Nubiology
- Krystyna Mihułka, author
- Ludwig von Mises, free-market economist (born in Lemberg)
- Richard von Mises, mathematician (younger brother of Ludwig, also born in Lemberg)
- Izydor Modelski, Polish Lieutenant General and spy
- Iryna Morykvas, Ukrainian illustrator, artist, writer
- Sigmund Mogulesko, Yiddish singer and actor
- Ignacy Mościcki, chemist and President of Poland (1926–1939)
- Andrzej Mostowski, mathematician
- Gabriela Moyseowicz, composer and pianist
- Paul Muni, actor
- Ana Muzičuk, chess grandmaster
- Vitaly Mansky, film director
- Leopold von Sacher-Masoch, journalist and BDSM writer whose surname originated the term "masochism"
- Henryk Samsonowicz, historian
- Iryna Senyk (1926-2009), poet, nurse, political dissident
- Filip Schleicher (1870-1932), Polish-Jewish lawyer, deputy mayor from 1913 to 1927
- Larisa Shepitko, Soviet film director.
- Andrey Sheptytsky, head of the Ukrainian Church through both the world wars
- Roman Shukhevych, general of the Ukrainian Insurgent Army
- Iva Sidash, Ukrainian street and documentary photographer
- Adam Mikołaj Sieniawski, hetman
- Stanisław Skrowaczewski, composer
- Myroslav Skoryk, composer, Hero of Ukraine
- Natalka Sniadanko, Ukrainian writer, journalist, translator
- Wacław Sobieski, historian
- Leopold Staff, poet
- Hugo Steinhaus, mathematician
- Zygmunt Steuermann (1899–1941), Polish football player
- Julian Stryjkowski, writer
- Roman Svintsitskyi (born 1981), former Ukrainian professional footballer
- Jan Szeliga ( ? — 1636), wandering book printer
- Moritz Szeps, journalist
- Wacław Szybalski, medical researcher
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