Africa is a surname. Notable people with the surname include:
- Candido Africa (1895–1945), Filipino medical researcher
- Dale Africa (born 1981), West Indian cricketer
- John Africa (1931–1985), born Vincent Leaphart, founder of MOVE, a Philadelphia-based predominantly black organization
- Keagan Africa (born 1985), former South African cricketer
- Melrick Africa (born 1978), Namibian rugby union centre and wing
- Susan Africa (born 1959), Filipino actress