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List of largest selling pharmaceutical products

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Best selling pharmaceuticals of U.S. market

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The top 5 best selling pharmaceuticals 2015–2019. Sales in billion USD.[1]

Rank Drug Main indication Trade name 2015 2016 2017 2018 2019
1 adalimumab rheumatoid arthritis Humira 10.1 13.5 16.3 18.4 21.4
2 apixaban anticoagulant Eliquis 1.6 3.0 4.6 7.1 9.9
3 etanercept rheumatoid arthritis Enbrel 7.2 7.6 7.9 8.0 8.1
4 ustekinumab psoriasis Stelara 2.0 2.6 3.7 5.0 6.6
5 pembrolizumab oncology Keytruda 0.4 0.7 2.2 4.3 6.5

Best selling pharmaceuticals of 2017/18

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The top 16 best selling pharmaceuticals of 2017/18.[2]

Rank Drug Main indication Trade name 2018 sales (million USD) 2017 sales (million USD)
1 adalimumab rheumatoid arthritis Humira 19 936 18427
3 apixaban anticoagulant Eliquis 9872 7395
4 lenalidomide multiple myeloma Revlimid 9685 8187
5 nivolumab oncology Opdivo 7570 5763
6 pembrolizumab oncology Keytruda 7171 3809
7 etanercept rheumatoid arthritis Enbrel 7126 7885
8 trastuzumab breast cancer Herceptin 6981 7013
9 bevacizumab colon cancer Avastin 6847 6686
10 rituximab non-Hodgkin's lymphoma Rituxan,

MabThera

6750 7298
11 rivaroxaban anticoagulant Xarelto 6589 6234
12 aflibercept Eylea 6551 5830
13 infliximab Remicade 5908 7152
14 Pneumococcal conjugate vaccine Prevnar 13

Prevenar 13

5802 5601
15 ustekinumab Stelara 5156 4011
16 pregabalin epilepsy Lyrica 4970 5065

Largest selling pharmaceutical products of 2015

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Drugs with sales above $5 billion in 2015 included: [3] [4]

Rank Drug Trade name Type Main indications Company Sales (USD millions/year) ∆ vs 2014
1 Adalimumab Humira Biologic Rheumatoid arthritis AbbVie Inc. 14,012 1,469
2 Ledipasvir/sofosbuvir Harvoni Small molecule Hepatitis C Gilead Sciences 13,864 11,737
3 Etanercept Enbrel Biologic Rheumatoid arthritis Amgen

Pfizer

8,697 4,009
4 Infliximab Remicade Biologic Crohn's Disease
Rheumatoid Arthritis 		Johnson & Johnson 8,355 1,487
5 Rituximab Mabthera

Rituxan

Biologic Lymphoma

Leukemia

Autoimmune disorders

Roche

Genentech

7,115 1,456
6 Insulin glargine Lantus Biologic Diabetes mellitus Sanofi 7,029 51
7 Bevacizumab Avastin Biologic Metastatic cancers Roche

Genentech

6,751 270
8 Trastuzumab Herceptin Biologic Breast cancer Roche

Genentech

6,603 265
9 Lenalidomide Revlimid Small molecule Multiple myeloma

Myelodysplastic syndromes

Celgene 5,801 821
10 Sofosbuvir Sovaldi Small molecule Hepatitis C Gilead Sciences 5,276 (5,007)
11 Fluticasone propionate/salmeterol Seretide

Advair

Small molecule Asthma

Chronic obstructive pulmonary disease

GlaxoSmithKline 5,227 (778)
12 Rosuvastatin Crestor Small molecule Cardiovascular diseases AstraZeneca 5,017 (495)

Best selling pharmaceuticals of 2013

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For the fourth quarter of 2013, the largest selling drugs were:[5]

Rank Brand Name(s) Generic Name Sales Q1 2014 Sales ($000) Change from Q4 2013 Company(ies) Disease/Medical Use First Approval Date Patent Expiration Date[6][7]
1 Abilify Aripiprazole 1,602,329 2.23% Generic Psychosis, mania, and depression Nov-2002 2014-Oct
2 Humira Adalimumab 1,561,861 3.86% AbbVie Crohn's disease; Rheumatoid arthritis Dec-2002 2016-Dec
3 Nexium Esomeprazole 1,536,435 0.74% Generic Gastrointestinal disorders Mar-2000 2014-May
4 Crestor Rosuvastatin 1,333,502 4.53% AstraZeneca, Shionogi Cholesterol Nov-2002 2016-Jul
5 Enbrel Etanercept 1,189,844 1.46% Amgen Rheumatoid arthritis Nov-1998 2012-Oct
6 Advair Diskus, Seretide Fluticasone/salmeterol 1,147,330 2.65% GlaxoSmithKline Asthma Aug-2000 2012-Mar
8 Remicade Infliximab 994,020 -2.71% Centocor Ortho Biotech, Inc., Mitsubishi Tanabe Pharma Crohn's disease; rheumatoid arthritis Aug-1998 n/a
9 Lantus Solostar Insulin glargine 939,691 9.39% Sanofi-Aventis Diabetes mellitus type 1 and 2 Apr-2000 2011-Dec
10 Neulasta Pegfilgrastim 854,508 -4.90% Amgen Neutropenia Jan-2002 Mon-20XX
11 Copaxone Glatiramer 851,351 -4.69% Generic Multiple sclerosis Dec-1996 Nov-2014
12 Rituxan, MabThera Rituximab 746,766 -0.16% Biogen Idec, Chugai Pharmaceutical, Genentech/Roche Non-Hodgkin’s lymphoma; rheumatoid arthritis Nov-1997 Mon-20XX
13 Spiriva Tiotropium bromide 726,057 3.39% Boehringer Ingelheim Chronic obstructive pulmonary disease Apr-2002 2018-Jul
14 Januvia Sitagliptin 700,941 3.63% Merck & Co., Inc. Diabetes mellitus type 2 Dec-1996 2017-Nov
15 Lantus Insulin glargine 685,461 5.84% Sanofi-Aventis Diabetes mellitus type 1 and 2 Apr-2000 Dec-2011
16 Atripla Emtricitabine/tenofovir/efavirenz 679,418 0.36% Gilead Sciences, Inc. HIV infection Dec-1996 Mar-2015
17 Cymbalta Duloxetine 664,186 -23.06% Generic Depression; anxiety disorders Aug-2004 Dec-2013
18 Avastin Bevacizumab 650,208 -1.25% Genentech/Roche Cancer Feb-2004 Mon-20XX
19 Lyrica Pregabalin 624,774 2.82% Pfizer Neuropathic pain Jul-2004 Jul-2019
20 OxyContin Oxycodone 585,482 -2.91% Generic Pain Dec-1996 Mon-20XX
21 Celebrex Celecoxib 580,332 5.23% Generic Osteoarthritis; rheumatoid arthritis Dec-1998 May-2014
22 Epogen Epoetin alfa 503,493 -2.08% Amgen Anemia Jun-1989 Mon-20XX
23 Truvada Tenofovir/emtricitabine 542,846 0.03% Gilead Sciences HIV infection Aug-2004 Mon-20XX
24 Diovan Valsartan 533,924 -2.80% Generic Hypertension Dec-1996 Sep-2012
25 Levemir Insulin detemir 424,186 9.34% Novo Nordisk Diabetes mellitus type 1 and 2 Dec-1990 Mon-20XX
26 Gleevec, Glivec Imatinib 498,149 7.22% Novartis Leukemia May-2001 Jan-2015
27 Herceptin Trastuzumab 473,632 1.53% Chugai Pharmaceutical, Genentech/Roche Breast cancer Sep-1998 Mon-20XX
28 Vyvanse Lisdexamfetamine 447,188 9.39% Shire Attention deficit hyperactivity disorder Apr-2008 Mon-20XX
29 Lucentis Ranibizumab 460,621 -0.84% Genentech Macular degeneration Dec-1990 Mon-20XX
30 Zetia Ezetimibe 444,731 4.04% Merck & Co., Schering-Plough Cholesterol Oct-2002 2017-Oct
31 Combivent Ipratropium bromide/salbutamol 391,404 20.28% Boehringer Ingelheim Chronic obstructive pulmonary disease Oct-1996 Mon-20XX
32 Symbicort Budesonide/formoterol 407,646 9.63% AstraZeneca Asthma Aug-2000 Mon-20XX
33 Namenda Memantine 434,766 -6.00% Generic Alzheimer's disease Oct-2003 Apr-2014 [9]
34 NovoLog FlexPen Insulin aspart 364,870 7.84% Novo Nordisk Diabetes mellitus type 1 and 2 Oct-1996 Mon-20XX
35 Xarelto Rivaroxaban 321,462 18.72% Bayer Oral anticoagulant Dec-1996 Sep-2012
36 NovoLog Insulin aspart 344,235 3.86% Novo Nordisk Diabetes mellitus type 1 and 2 Oct-1996 Mon-20XX
37 Humalog Insulin lispro 304,866 6.15% Eli Lilly and Company Diabetes mellitus type 1 and 2 Apr-1996 Mon-20XX
38 Suboxone Buprenorphine 321,892 -2.11% Reckitt Benckiser Pharmaceuticals Inc. Pain; opioid addiction Aug-2000 Mon-20XX
40 Viagra Sildenafil 300,463 3.26% Pfizer Erectile dysfunction Mar-1998 Mar-2012
41 Seroquel XR Quetiapine 291,494 2.22% Generic Psychosis; depression Sep-1997 Mar-2012
33 Incivo Telaprevir 370,899 0.00% Johnson & Johnson Hepatitis C[citation needed] Dec-1990 Mon-20XX
35 AndroGel Testosterone gel 351,737 5.47% Generic Low testosterone levels Oct-2002 Oct-2016
37 Enoxaparin Enoxaparin 341,184 6.55% Generic Deep-vein thrombosis Mar-1993 2012-Aug
38 Ritalin Methylphenidate 327,346 2.26% Generic Attention deficit hyperactivity disorder Aug-2000 Mon-20XX
41 ProAir HFA Salbutamol 306,461 10.87% Teva Pharmaceuticals Asthma; chronic obstructive pulmonary disease Oct-1996 Mon-20XX
43 Alimta Pemetrexed 302,728 6.00% Eli Lilly and Company Cancer Feb-2004 Mon-20XX
44 Victoza Liraglutide 301,414 9.59% Novo Nordisk Diabetes mellitus type 2 May-1909 Mon-20XX
47 Synagis Palivizumab 289,704 0.00% MedImmune RSV infection Feb-1998 Aug-2012
48 Avonex Interferon beta 1a 281,554 -1.43% Biogen Idec Multiple sclerosis May-1996 Mon-20XX
49 Renvela Sevelamer 280,917 21.44% Generic Hyperphosphatemia Apr-2002 Apr-2016 [10]
50 Rebif Interferon beta 1a 280,548 -6.27% Serono Multiple sclerosis Feb-1998 Mon-20XX
51 Cialis Tadalafil 280,518 4.58% Eli Lilly and Company, Lilly Icos Erectile dysfunction Nov-2002 2017-Nov
52 Gilenya fingolimod 272,701 4.05% Novartis Corporation Multiple sclerosis Feb-2000 2007-Jan
53 Nasonex Mometasone 272,345 5.67% Schering-Plough Allergic rhinitis Oct-1997 2018-Oct
54 Stelara Ustekinumab 270,598 12.47% Johnson & Johnson Psoriasis; psoriatic arthritis Apr-2000 Mon-20XX
55 Restasis Ciclosporin ophthalmic emulsion 268,463 6.30% Allergan, Inc, Lilly Icos Dry eye syndrome Nov-2002 Mon-20XX
56 Budesonide Budesonide 268,201 26.81% Generic Asthma Aug-2000 Mon-20XX
57 Acetaminophen/hydrocodone Acetaminophen/hydrocodone 264,814 6.67% Generic Pain Aug-2000 Mon-20XX
58 Flovent HFA Fluticasone propionate 263,072 13.97% GlaxoSmithKline Asthma Mar-1996 Mon-20XX
59 Lovaza Omega-3 fatty acid ethyl esters 258,177 2.90% GlaxoSmithKline Cholesterol Jun-2001 Mon-20XX
60 Prezista Darunavir 251,372 3.54% Johnson & Johnson HIV infection Jun-2006 Mon-20XX
61 Isentress Raltegravir 248,924 0.72% Merck & Co., Inc. HIV Infection Dec-1998 Mon-20XX
62 Janumet Sitagliptin/metformin 247,150 4.65% Merck & Co., Inc. Diabetes mellitus type 2 Dec-1998 Mon-20XX
63 Procrit, Eprex Epoetin alfa 241,535 -10.09% Johnson & Johnson Anemia Dec-1990 Mon-20XX
64 Doxycycline Doxycycline 241,381 -5.65% Generic Bacterial infections Dec-1996 Nov-2011
65 Orencia Abatacept 241,149 1.65% Bristol-Myers Squibb Company Rheumatoid arthritis Aug-2000 Mon-20XX
66 Amphetamine/dextroamphetamine Amphetamine mixed salts 240,482 2.78% Generic Attention deficit hyperactivity disorder; narcolepsy Feb-2004 Mon-20XX
67 Vesicare Solifenacin 240,435 5.37% Astellas Pharma US Overactive bladder Feb-2000 2018-Nov
68 Dexilant Dexlansoprazole 238,897 7.57% Takeda Pharmaceuticals North America, Inc Gastrointestinal disorders Dec-2004 Jul-2012
69 Humalog KwikPen Insulin lispro 238,418 11.02% Eli Lilly and Company Diabetes mellitus type 1 and 2 Apr-1996 Mon-20XX
70 Neupogen Filgrastim 229,912 -2.70% Amgen Neutropenia Feb-1991 Mon-20XX
71 Lidocaine Lidocaine 225,903 0.00% Generic Pain Mar-1999 Mon-20XX
72 Lunesta Eszopiclone 225,101 5.24% Generic Insomnia Dec-2004 April-2015
73 Fenofibrate Fenofibrate 223,300 -2.22% Generic Cholesterol Feb-1998 Mon-20XX
74 Zytiga Abiraterone 222,026 11.86% Janssen Biotech, Inc. Prostate Cancer Dec-1998 April-2015
75 Reyataz Atazanavir 217,793 -1.38% Bristol-Myers Squibb HIV infection Jan-2003 Mon-20XX
76 Sensipar Cinacalcet 216,657 13.71% Amgen Inc. Hyperparathyroidism Apr-2000 Mon-20XX
77 Metoprolol Metoprolol 215,111 2.99% Generic Hypertension Jan-1992 Mon-20XX
78 AcipHex Rabeprazole 214,251 10.03% Janssen Pharmaceuticals, Inc, Johnson & Johnson Gastrointestinal disorders Aug-1999 Nov-2013
79 Synthroid Levothyroxine 213,424 -2.50% Generic Hypothyroidism May-1999 Expired
80 Avonex Pen Olmesartan 211,917 13.59% Biogen Idec, Forest Laboratories Hypertension Apr-2002 Apr-2016
81 Prevnar 13 Pneumococcal conjugate vaccine 209,367 6.41% Pfizer Pneumococcal disease Feb-2000 Jan-2007
82 Xolair Omalizumab 207,891 1.91% Genentech, Novartis Asthma 2003 Mon-20XX
83 Lipitor Atorvastatin 207,542 4.23% Generic Cholesterol Dec-1996 Nov-2011 [12]
84 levothyroxine Levothyroxine 204,755 0.00% Generic Hypothyroidism Aug-1990 Mon-20XX
85 Benicar Olmesartan/hydrochlorothiazide 203,336 3.22% Daiichi Sankyo Hypertension Jun-1909 Mon-2016
86 Stribild Elvitegravir/cobicistat/emtricitabine/tenofovir 202,642 0.00% Gilead Sciences HIV/AIDS Apr-2000 Mon-20XX[13]
87 Zostavax Zostavax 202,240 15.17% Eisai, Merck & Co. Herpes zoster Aug-1999 May-2013
88 Pradaxa Dabigatran 200,697 -0.53% Boehringer Ingelheim, Lilly Icos Oral anticoagulant Oct-2010 Mon-20XX
89 Vytorin Ezetimibe/simvastatin 199,625 -3.02% Merck & Co., Schering-Plough Cholesterol Jul-2004 Mon-20XX
90 Tamiflu Oseltamivir 197,718 0.00% Chugai Pharmaceutical, Hetero Drugs, Roche Influenza Oct-1999 Mon-20XX
91 Xgeva Denosumab 197,711 3.24% Amgen Osteoporosis Nov-2010 Mon-20XX
92 Evista Raloxifene 196,929 -4.31% Eli Lilly and Company, Chugai Pharmaceutical Osteoporosis Dec-1997 Jan-2013
93 Xeloda Capecitabine 194,044 6.52% Generic Cancer Jun-1909 Mon-20XX [14]
94 Aranesp Darbepoetin alfa 185,225 -9.22% Amgen Inc. Anemia Jun-2001 Mon-20XX
95 Ventolin HFA Salbutamol 183,060 0.00% GlaxoSmithKline Asthma; chronic obstructive pulmonary disease May-1981 Mon-20XX
96 divalproex sodium Valproate 181,554 0.00% Generic Epilepsy and bipolar disorder [15] Jun-1909 Mon-20XX
97 Afinitor Everolimus 180,719 0.03% Novartis Cancer Jun-1909 Mon-20XX
98 Betaseron, Betaferon Interferon beta 1b 179,216 -3.72% Bayer Multiple sclerosis Jul-1993 Mon-20XX
99 Adderall XR Amphetamine mixed salts 177,505 3.31% Generic Attention deficit hyperactivity disorder Oct-2001 Mon-20XX
100 Complera Emtricitabine/Rilpivirine/Tenofovir disoproxil fumarate 174,933 0.00% Gilead Sciences, Inc. HIV Jun-20XX Mon-20XX

See also

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References

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  1. ^ "Medicine Spending and Affordability in the United States: Understanding Patients' Costs for Medicines". IQVIA Institute for Human Data Science. Archived from the original on 17 Sep 2020.
  2. ^ "Top 15 Best-Selling Drugs of 2018". GEN - Genetic Engineering and Biotechnology News. 2019-03-11. Retrieved 2019-05-30.
  3. ^ "The Top 15 Best-Selling Drugs of 2016". 6 March 2017.
  4. ^ "Top drugs by sales revenue in 2015: Who sold the biggest blockbuster drugs?". March 10, 2016. Retrieved October 19, 2016.
  5. ^ Drugs.com U.S. Pharmaceutical Sales - Q4 2013, updated Feb. 2014
  6. ^ Patent Terms Extended Under 35 USC §156
  7. ^ Orange Book Trade Name Search
  8. ^ "Generic OxyContin Availability". Drugs.com.
  9. ^ Unknown. "Generic Namenda Availability - Drugs.com". www.drugs.com. Drugs.com. Retrieved 21 December 2015.
  10. ^ Donohue, Mark. "Impax Laboratories Inc. - Impax Launches Authorized Generic RENVELA®". investors.impaxlabs.com. Impax Laboratories. Retrieved 21 December 2015.
  11. ^ Armstrong, Drew; Decker, Susan. "Pfizer's blockbuster blue pill Viagra set to go generic in 2015". Indianapolis Star. Retrieved 25 December 2015.
  12. ^ "Atorvastatin: Drug Uses, Dosage, Side Effects - Drugs.com". www.drugs.com. drugs.com. Retrieved 21 December 2015.
  13. ^ "HIV Treatment". www.stribild.com.
  14. ^ Walsh, Sandy. "Press Announcements - FDA approves first generic capecitabine to treat colorectal and breast cancers". www.fda.gov. United States Food and Drug Administration. Retrieved 21 December 2015.
  15. ^ "Valproic Acid". The American Society of Health-System Pharmacists. Archived from the original on 2017-07-31. Retrieved Oct 23, 2015.
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