Lorenzetti is an Italian surname. Notable people with the surname include:
- Ambrogio Lorenzetti (c. 1290–1348), Sienese painter
- Enrico Lorenzetti (1911–1989), Italian motorcycle road racer
- Gustavo Lorenzetti (born 1985), Argentine footballer
- Pietro Lorenzetti (c. 1280–1348), Sienese painter, brother of Ambrogio Lorenzetti
- Ricardo Lorenzetti (born 1955), Argentine judge