Luis Maldonado may refer to:
- Luis Maldonado (politician) (born 1954), Puerto Rican politician, mayor of Ciales
- Luis Maldonado (bishop) (died 1596), Roman Catholic bishop of Nueva Caceres
- Luis Maldonado (footballer, born 1985), Uruguayan footballer
- Luis Maldonado (footballer, born 1996), Ecuadorian footballer
- Luis Maldonado Jr., Paraguayan rally driver
- Luis Maldonado (musician), member of Train and Foreigner