LSP1

Lymphocyte-specific protein 1 is a protein that in humans is encoded by the LSP1 gene.

LSP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3BH8, 4NO0, 4NO2
Identifiers
Aliases	LSP1, WP34, pp52, lymphocyte-specific protein 1, lymphocyte specific protein 1
External IDs	OMIM: 153432; MGI: 96832; HomoloGene: 1750; GeneCards: LSP1; OMA:LSP1 - orthologs
Gene location (Human) Chr. Chromosome 11 (human) Band 11p15.5 Start 1,850,904 bp End 1,892,267 bp
Gene location (Mouse) Chr. Chromosome 7 (mouse) Band 7 F5|7 87.93 cM Start 142,014,546 bp End 142,048,604 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte blood monocyte spleen appendix bone marrow cells right adrenal cortex lymph node left adrenal gland left adrenal cortex Top expressed in granulocyte thymus mesenteric lymph nodes tibiofemoral joint vas deferens spleen uterus lip efferent ductule blood More reference expression data BioGPS More reference expression data
Gene ontology Molecular function actin binding signal transducer activity Cellular component extracellular exosome actin cytoskeleton membrane plasma membrane Biological process chemotaxis cellular defense response defense response signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4046 16985 Ensembl ENSG00000130592 ENSG00000288199 ENSMUSG00000018819 UniProt P33241 P19973 RefSeq (mRNA) NM_002339 NM_001013253 NM_001013254 NM_001013255 NM_001242932 NM_001289005 NM_001136071 NM_001271508 NM_001271509 NM_001271510 NM_001271523 NM_019391 RefSeq (protein) NP_001013271 NP_001013272 NP_001013273 NP_001229861 NP_001275934 NP_002330 NP_001129543 NP_001258437 NP_001258438 NP_001258439 NP_001258452 NP_062264 Location (UCSC) Chr 11: 1.85 – 1.89 Mb Chr 7: 142.01 – 142.05 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes an intracellular F-actin binding protein. The protein is expressed in lymphocytes, neutrophils, macrophages, and endothelium and may regulate neutrophil motility, adhesion to fibrinogen matrix proteins, and transendothelial migration. Alternative splicing results in multiple transcript variants encoding different isoforms.

Further reading

• Jongstra-Bilen J, Young AJ, Chong R, Jongstra J (1990). "Human and mouse LSP1 genes code for highly conserved phosphoproteins". J. Immunol. 144 (3): 1104–10. doi:10.4049/jimmunol.144.3.1104. PMID 2295815.
• Klein DP, Jongstra-Bilen J, Ogryzlo K, Chong R, Jongstra J (1989). "Lymphocyte-specific Ca2+-binding protein LSP1 is associated with the cytoplasmic face of the plasma membrane". Mol. Cell. Biol. 9 (7): 3043–8. doi:10.1128/mcb.9.7.3043. PMC 362773. PMID 2674678.
• Li Y, Guerrero A, Howard TH (1995). "The actin-binding protein, lymphocyte-specific protein 1, is expressed in human leukocytes and human myeloid and lymphoid cell lines". J. Immunol. 155 (7): 3563–9. doi:10.4049/jimmunol.155.7.3563. PMID 7561054.
• Misener VL, Hui C, Malapitan IA, Ittel ME, Joyner AL, Jongstra J (1995). "Expression of mouse LSP1/S37 isoforms. S37 is expressed in embryonic mesenchymal cells". J. Cell Sci. 107 (12): 3591–600. doi:10.1242/jcs.107.12.3591. PMID 7706408.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Howard T, Li Y, Torres M, Guerrero A, Coates T (1994). "The 47-kD protein increased in neutrophil actin dysfunction with 47- and 89-kD protein abnormalities is lymphocyte-specific protein". Blood. 83 (1): 231–41. doi:10.1182/blood.V83.1.231.231. PMID 8274738.
• May W, Korenberg JR, Chen XN, Lunsford L, Wood WJ, Thompson A, Wall R, Denny CT (1993). "Human lymphocyte-specific pp52 gene is a member of a highly conserved dispersed family". Genomics. 15 (3): 515–20. doi:10.1006/geno.1993.1102. PMID 8468046.
• Thompson AA, Omori SA, Gilly MJ, May W, Gordon MS, Wood J, Miyoshi E, Malone CS, Gimble J (1997). "Alternatively spliced exons encode the tissue-specific 5' termini of leukocyte pp52 and stromal cell S37 mRNA isoforms". Genomics. 32 (3): 352–7. doi:10.1006/geno.1996.0129. PMID 8838798.
• Huang CK, Zhan L, Ai Y, Jongstra J (1997). "LSP1 is the major substrate for mitogen-activated protein kinase-activated protein kinase 2 in human neutrophils". J. Biol. Chem. 272 (1): 17–9. doi:10.1074/jbc.272.1.17. PMID 8995217.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Palker TJ, Fong AM, Scearce RM, Patel DD, Haynes BF (1999). "Developmental regulation of lymphocyte-specific protein 1 (LSP1) expression in thymus during human T-cell maturation". Hybridoma. 17 (6): 497–507. doi:10.1089/hyb.1998.17.497. PMID 9890705.
• Pulford K, Jones M, Banham AH, Haralambieva E, Mason DY (1999). "Lymphocyte-specific protein 1: a specific marker of human leucocytes". Immunology. 96 (2): 262–71. doi:10.1046/j.1365-2567.1999.00677.x. PMC 2326732. PMID 10233704.
• Zhang Q, Li Y, Howard TH (2000). "Human lymphocyte-specific protein 1, the protein overexpressed in neutrophil actin dysfunction with 47-kDa and 89-kDa protein abnormalities (NAD 47/89), has multiple F-actin binding domains". J. Immunol. 165 (4): 2052–8. doi:10.4049/jimmunol.165.4.2052. PMID 10925289.
• Zhang Q, Li Y, Howard TH (2002). "Hair-forming activity of human lymphocyte specific protein 1 requires cooperation between its caldesmon-like domains and the villin headpiece-like domains". Cell Motil. Cytoskeleton. 49 (4): 179–88. doi:10.1002/cm.1031. PMID 11746662.
• Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Wong MJ, Malapitan IA, Sikorski BA, Jongstra J (2003). "A cell-free binding assay maps the LSP1 cytoskeletal binding site to the COOH-terminal 30 amino acids". Biochim. Biophys. Acta. 1642 (1–2): 17–24. doi:10.1016/S0167-4889(03)00082-X. PMID 12972289.
• Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Harrison RE, Sikorski BA, Jongstra J (2005). "Leukocyte-specific protein 1 targets the ERK/MAP kinase scaffold protein KSR and MEK1 and ERK2 to the actin cytoskeleton". J. Cell Sci. 117 (Pt 10): 2151–7. doi:10.1242/jcs.00955. PMID 15090600. S2CID 11827355.
• Hassel S, Eichner A, Yakymovych M, Hellman U, Knaus P, Souchelnytskyi S (2004). "Proteins associated with type II bone morphogenetic protein receptor (BMPR-II) and identified by two-dimensional gel electrophoresis and mass spectrometry". Proteomics. 4 (5): 1346–58. doi:10.1002/pmic.200300770. PMID 15188402. S2CID 6773754.