Lyonnaise or Lyonnais may refer to:
- Lyonnais (masculine) and Lyonnaise (feminine), something from or relating to Lyon, a city in France
- Gaule Lyonnaise, French name of Gallia Lugdunensis, a province of the Roman Empire
- Lyonnais, a historical province of France
- Lyonnaise cuisine
- Lyonnaise, cooked with onions
- Lyonnaise (grape), another name for the Swiss wine grape Räuschling