MGAT5

Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A is an enzyme that in humans is encoded by the MGAT5 gene.

MGAT5
Identifiers
Aliases	MGAT5, GNT-V, GNT-VA, mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase, MGAT5A, glcNAc-T V
External IDs	OMIM: 601774; MGI: 894701; HomoloGene: 1808; GeneCards: MGAT5; OMA:MGAT5 - orthologs
Gene location (Human) Chr. Chromosome 2 (human) Band 2q21.2-q21.3 Start 134,119,983 bp End 134,454,621 bp
Gene location (Mouse) Chr. Chromosome 1 (mouse) Band 1|1 E3 Start 127,132,752 bp End 127,416,073 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in glomerulus metanephric glomerulus middle temporal gyrus Brodmann area 23 tibia pons cardiac muscle tissue of right atrium pars reticulata bronchial epithelial cell myocardium of left ventricle Top expressed in Paneth cell renal corpuscle medial geniculate nucleus molar pontine nuclei lateral geniculate nucleus pituitary gland median eminence habenula substantia nigra More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity acetylglucosaminyltransferase activity glycosyltransferase activity alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity protein phosphatase inhibitor activity manganese ion binding Cellular component integral component of membrane Golgi membrane extracellular exosome membrane Golgi apparatus extracellular region Biological process protein glycosylation protein N-linked glycosylation protein N-linked glycosylation via asparagine positive regulation of cell migration negative regulation of protein tyrosine phosphatase activity positive regulation of receptor signaling pathway via STAT Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4249 107895 Ensembl ENSG00000152127 ENSMUSG00000036155 UniProt Q09328 Q8R4G6 RefSeq (mRNA) NM_002410 NM_001371457 NM_145128 RefSeq (protein) NP_002401 NP_001358386 NP_660110 Location (UCSC) Chr 2: 134.12 – 134.45 Mb Chr 1: 127.13 – 127.42 Mb PubMed search
Wikidata
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This gene encodes mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, a glycosyltransferase involved in the synthesis of protein-bound and lipid-bound oligosaccharides. Alterations of the oligosaccharides on cell surface glycoproteins cause significant changes in the adhesive or migratory behavior of a cell. Increase in the encoded protein's activity may correlate with the progression of invasive malignancies.

Further reading

• Dennis JW, Granovsky M, Warren CE (2000). "Glycoprotein glycosylation and cancer progression". Biochim. Biophys. Acta. 1473 (1): 21–34. doi:10.1016/s0304-4165(99)00167-1. PMID 10580127.
• Buckhaults P, Chen L, Fregien N, Pierce M (1997). "Transcriptional regulation of N-acetylglucosaminyltransferase V by the src oncogene". J. Biol. Chem. 272 (31): 19575–81. doi:10.1074/jbc.272.31.19575. PMID 9235963.
• Park C, Jin UH, Lee YC, et al. (1999). "Characterization of UDP-N-acetylglucosamine:alpha-6-d-mannoside beta-1,6-N-acetylglucosaminyltransferase V from a human hepatoma cell line Hep3B". Arch. Biochem. Biophys. 367 (2): 281–8. doi:10.1006/abbi.1999.1252. PMID 10395745.
• Granovsky M, Fata J, Pawling J, et al. (2000). "Suppression of tumor growth and metastasis in Mgat5-deficient mice". Nat. Med. 6 (3): 306–12. doi:10.1038/73163. PMID 10700233. S2CID 1950342.
• Ihara S, Miyoshi E, Ko JH, et al. (2002). "Prometastatic effect of N-acetylglucosaminyltransferase V is due to modification and stabilization of active matriptase by adding beta 1-6 GlcNAc branching". J. Biol. Chem. 277 (19): 16960–7. doi:10.1074/jbc.M200673200. PMID 11864986.
• Saito T, Miyoshi E, Sasai K, et al. (2002). "A secreted type of beta 1,6-N-acetylglucosaminyltransferase V (GnT-V) induces tumor angiogenesis without mediation of glycosylation: a novel function of GnT-V distinct from the original glycosyltransferase activity". J. Biol. Chem. 277 (19): 17002–8. doi:10.1074/jbc.M200521200. PMID 11872751.
• Dosaka-Akita H, Miyoshi E, Suzuki O, et al. (2004). "Expression of N-acetylglucosaminyltransferase v is associated with prognosis and histology in non-small cell lung cancers". Clin. Cancer Res. 10 (5): 1773–9. doi:10.1158/1078-0432.CCR-1047-3. PMID 15014031. S2CID 14246685.
• Guo P, Zhang Y, Shen ZH, et al. (2004). "Effect of N-acetylglucosaminyltransferase V on the expressions of other glycosyltransferases". FEBS Lett. 562 (1–3): 93–8. doi:10.1016/S0014-5793(04)00188-7. PMID 15044007. S2CID 42049140.
• Kim CH (2005). "Increased expression of N-acetylglucosaminyltransferase-V in human hepatoma cells by retinoic acid and 1alpha,25-dihydroxyvitamin D3". Int. J. Biochem. Cell Biol. 36 (11): 2307–19. doi:10.1016/j.biocel.2004.04.021. PMID 15313475.
• Tomiie M, Isaka S, Miyoshi E, et al. (2005). "Elevated expression of N-acetylglucosaminyltransferase V in first trimester human placenta". Biochem. Biophys. Res. Commun. 330 (3): 999–1004. doi:10.1016/j.bbrc.2005.02.186. PMID 15809094.
• Fang H, Huang W, Xu YY, et al. (2006). "Blocking of N-acetylglucosaminyltransferase V induces cellular endoplasmic reticulum stress in human hepatocarcinoma 7,721 cells". Cell Res. 16 (1): 82–92. doi:10.1038/sj.cr.7310011. PMID 16467879.
• Ishimura H, Takahashi T, Nakagawa H, et al. (2006). "N-acetylglucosaminyltransferase V and beta1-6 branching N-linked oligosaccharides are associated with good prognosis of patients with bladder cancer". Clin. Cancer Res. 12 (8): 2506–11. doi:10.1158/1078-0432.CCR-05-1938. PMID 16638859.
• Wang L, Liang Y, Li Z, et al. (2007). "Increase in beta1-6 GlcNAc branching caused by N-acetylglucosaminyltransferase V directs integrin beta1 stability in human hepatocellular carcinoma cell line SMMC-7721". J. Cell. Biochem. 100 (1): 230–41. doi:10.1002/jcb.21071. PMID 16924681. S2CID 11808116.
• Li J, Wang XM, Wang Q, et al. (2007). "Down-regulation of N-acetylglucosaminyltransferase-V induces ER stress by changing glycosylation and function of GLUT1". Arch. Biochem. Biophys. 463 (1): 102–9. doi:10.1016/j.abb.2007.03.005. PMID 17451637.
• Kudo T, Nakagawa H, Takahashi M, et al. (2007). "N-glycan alterations are associated with drug resistance in human hepatocellular carcinoma". Mol. Cancer. 6 (1): 32. doi:10.1186/1476-4598-6-32. PMC 1878497. PMID 17488527.