MI8, MI-8, or another variant may refer to:
- AMD's MI8, a brand of deep learning oriented Graphics Processing Units, see Radeon Instinct
- MI8, the World War II British signals intelligence agency
- Mil Mi-8, the Soviet-designed helicopter
- Mitten im 8en, an Austrian TV soap/comedy series
- Black Chamber, the United States' first peacetime cryptanalytic organization
- Michigan's 8th congressional district
- M-8 (Michigan highway)
- Xiaomi Mi 8, smartphone developed by Xiaomi
- Mission: Impossible – The Final Reckoning, an upcoming spy-thriller film starring Tom Cruise
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