MIB1

For the protein antibody, see Ki-67 (protein) § MIB-1.

E3 ubiquitin-protein ligase MIB1 is an enzyme that in humans is encoded by the MIB1 gene. It is involved in regulating apoptosis.

MIB1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4TSE, 4XI6, 4XI7, 4XIB
Identifiers
Aliases	MIB1, DIP-1, DIP1, LVNC7, MIB, ZZANK2, ZZZ6, mindbomb E3 ubiquitin protein ligase 1, MIB E3 ubiquitin protein ligase 1
External IDs	OMIM: 608677; MGI: 2443157; HomoloGene: 10810; GeneCards: MIB1; OMA:MIB1 - orthologs
Gene location (Human) Chr. Chromosome 18 (human) Band 18q11.2 Start 21,704,957 bp End 21,870,953 bp
Gene location (Mouse) Chr. Chromosome 18 (mouse) Band 18|18 A1 Start 10,725,548 bp End 10,818,704 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in corpus epididymis tibia nipple caput epididymis parietal pleura tail of epididymis cartilage tissue corpus callosum visceral pleura secondary oocyte Top expressed in spermatid parotid gland ciliary body ureter dentate gyrus of hippocampal formation granule cell lacrimal gland iris Region I of hippocampus proper dorsal striatum spermatocyte More reference expression data BioGPS More reference expression data
Gene ontology Molecular function zinc ion binding metal ion binding protein binding ubiquitin-protein transferase activity transferase activity Cellular component cytoplasm cytosol centrosome membrane postsynaptic density plasma membrane microtubule organizing center cytoskeleton cytoplasmic vesicle Biological process somitogenesis endocytosis negative regulation of neuron differentiation in utero embryonic development heart looping positive regulation of endocytosis heart development blood vessel development protein ubiquitination neural tube formation Notch signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 57534 225164 Ensembl ENSG00000101752 ENSMUSG00000024294 UniProt Q86YT6 Q80SY4 RefSeq (mRNA) NM_020774 NM_144860 NM_001364997 RefSeq (protein) NP_065825 NP_659109 NP_001351926 Location (UCSC) Chr 18: 21.7 – 21.87 Mb Chr 18: 10.73 – 10.82 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Confusion with proliferative marker

An antibody directed at the protein Ki-67, a product of the MKI67 gene, is called MIB-1.

Further reading

• Nagase T, Kikuno R, Ishikawa KI, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (1): 65–73. doi:10.1093/dnares/7.1.65. PMID 10718198.
• Wang Z, Tseng CP, Pong RC, et al. (2002). "The mechanism of growth-inhibitory effect of DOC-2/DAB2 in prostate cancer. Characterization of a novel GTPase-activating protein associated with N-terminal domain of DOC-2/DAB2". J. Biol. Chem. 277 (15): 12622–31. doi:10.1074/jbc.M110568200. PMID 11812785.
• Jin Y, Blue EK, Dixon S, et al. (2003). "A death-associated protein kinase (DAPK)-interacting protein, DIP-1, is an E3 ubiquitin ligase that promotes tumor necrosis factor-induced apoptosis and regulates the cellular levels of DAPK". J. Biol. Chem. 277 (49): 46980–6. doi:10.1074/jbc.M208585200. PMC 2824503. PMID 12351649.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Itoh M, Kim CH, Palardy G, et al. (2003). "Mind bomb is a ubiquitin ligase that is essential for efficient activation of Notch signaling by Delta". Dev. Cell. 4 (1): 67–82. doi:10.1016/S1534-5807(02)00409-4. PMID 12530964.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Henshall DC, Schindler CK, So NK, et al. (2004). "Death-associated protein kinase expression in human temporal lobe epilepsy". Ann. Neurol. 55 (4): 485–94. doi:10.1002/ana.20001. PMID 15048887. S2CID 35261517.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Yoo KW, Kim EH, Jung SH, et al. (2006). "Snx5, as a Mind bomb-binding protein, is expressed in hematopoietic and endothelial precursor cells in zebrafish". FEBS Lett. 580 (18): 4409–16. doi:10.1016/j.febslet.2006.07.009. PMID 16857196. S2CID 37762815.
• Song R, Koo BK, Yoon KJ, et al. (2007). "Neuralized-2 regulates a Notch ligand in cooperation with Mind bomb-1". J. Biol. Chem. 281 (47): 36391–400. doi:10.1074/jbc.M606601200. PMID 17003037.
• Zhang L, Nephew KP, Gallagher PJ (2007). "Regulation of death-associated protein kinase. Stabilization by HSP90 heterocomplexes". J. Biol. Chem. 282 (16): 11795–804. doi:10.1074/jbc.M610430200. PMC 2823631. PMID 17324930.
• Yakut T, Gutenberg A, Bekar A, et al. (2007). "Correlation of chromosomal imbalances by comparative genomic hybridization and expression of EGFR, PTEN, p53, and MIB-1 in diffuse gliomas". Oncol. Rep. 17 (5): 1037–43. doi:10.3892/or.17.5.1037. PMID 17390041.
• van der Avoort IA, van der Laak JA, Paffen A, et al. (2007). "MIB1 expression in basal cell layer: a diagnostic tool to identify premalignancies of the vulva". Mod. Pathol. 20 (7): 770–8. doi:10.1038/modpathol.3800796. hdl:2066/51438. PMID 17464313.