Stromelysin-3 (SL-3) also known as matrix metalloproteinase-11 (MMP-11) is an enzyme that in humans is encoded by the MMP11 gene.[4][5][6][7]

MMP11
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesMMP11, SL-3, ST3, STMY3, matrix metallopeptidase 11
External IDsOMIM: 185261; MGI: 97008; HomoloGene: 38116; GeneCards: MMP11; OMA:MMP11 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005940

NM_008606
NM_001306184

RefSeq (protein)

NP_005931
NP_005931.2

NP_001293113
NP_032632

Location (UCSC)n/aChr 10: 75.76 – 75.77 Mb
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

Function

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Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the enzyme encoded by this gene is activated intracellularly by furin within the constitutive secretory pathway. Also in contrast to other MMPs, this enzyme cleaves alpha 1-proteinase inhibitor but weakly degrades structural proteins of the extracellular matrix.[7]

References

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  1. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000000901Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ Levy A, Zucman J, Delattre O, Mattei MG, Rio MC, Basset P (Aug 1992). "Assignment of the human stromelysin 3 (STMY3) gene to the q11.2 region of chromosome 22". Genomics. 13 (3): 881–3. doi:10.1016/0888-7543(92)90175-R. PMID 1639418.
  5. ^ Anglard P, Melot T, Guerin E, Thomas G, Basset P (Oct 1995). "Structure and promoter characterization of the human stromelysin-3 gene". J Biol Chem. 270 (35): 20337–44. doi:10.1074/jbc.270.35.20337. PMID 7657606.
  6. ^ Luo D, Mari B, Stoll I, Anglard P (Jul 2002). "Alternative splicing and promoter usage generates an intracellular stromelysin 3 isoform directly translated as an active matrix metalloproteinase". J Biol Chem. 277 (28): 25527–36. doi:10.1074/jbc.M202494200. PMID 12006591.
  7. ^ a b "Entrez Gene: MMP11 matrix metallopeptidase 11 (stromelysin 3)".

Further reading

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