Mitochondrial ribosomal protein L1

39S ribosomal protein L1, mitochondrial is a protein that in humans is encoded by the MRPL1 gene.

MRPL1
Identifiers
Aliases	MRPL1, BM022, L1MT, MRP-L1, mitochondrial ribosomal protein L1
External IDs	OMIM: 611821; MGI: 2137202; HomoloGene: 41355; GeneCards: MRPL1; OMA:MRPL1 - orthologs
Gene location (Human) Chr. Chromosome 4 (human) Band 4q21.1 Start 77,862,830 bp End 77,952,785 bp
Gene location (Mouse) Chr. Chromosome 5 (mouse) Band 5|5 E3 Start 96,357,352 bp End 96,414,586 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in myocardium of left ventricle Skeletal muscle tissue of rectus abdominis Skeletal muscle tissue of biceps brachii deltoid muscle quadriceps femoris muscle vastus lateralis muscle tibialis anterior muscle gonad muscle of thigh mucosa of transverse colon Top expressed in interventricular septum intercostal muscle myocardium of ventricle seminiferous tubule epithelium of small intestine soleus muscle left lobe of liver cumulus cell quadriceps femoris muscle epiblast More reference expression data BioGPS n/a
Gene ontology Molecular function structural constituent of ribosome protein binding RNA binding box H/ACA snoRNA binding Cellular component mitochondrial inner membrane large ribosomal subunit ribosome cytosolic large ribosomal subunit mitochondrion box H/ACA snoRNP complex Biological process mitochondrial translational elongation mitochondrial translational termination maturation of LSU-rRNA protein biosynthesis cleavage involved in rRNA processing rRNA pseudouridine synthesis snRNA pseudouridine synthesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 65008 94061 Ensembl ENSG00000169288 ENSMUSG00000029486 UniProt Q9BYD6 Q99N96 RefSeq (mRNA) NM_020236 NM_001039084 NM_053158 RefSeq (protein) NP_064621 NP_001034173 NP_444388 Location (UCSC) Chr 4: 77.86 – 77.95 Mb Chr 5: 96.36 – 96.41 Mb PubMed search
Wikidata
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Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the L1 ribosomal protein family.

Further reading

• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
• Suzuki T, Terasaki M, Takemoto-Hori C, et al. (2001). "Structural compensation for the deficit of rRNA with proteins in the mammalian mitochondrial ribosome. Systematic analysis of protein components of the large ribosomal subunit from mammalian mitochondria". J. Biol. Chem. 276 (24): 21724–36. doi:10.1074/jbc.M100432200. PMID 11279069.
• Kenmochi N, Suzuki T, Uechi T, et al. (2001). "The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders". Genomics. 77 (1–2): 65–70. doi:10.1006/geno.2001.6622. PMID 11543634.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Zhang Z, Gerstein M (2003). "Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome". Genomics. 81 (5): 468–80. doi:10.1016/S0888-7543(03)00004-1. PMID 12706105.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. Bibcode:2005Natur.434..724H. doi:10.1038/nature03466. PMID 15815621.
• Choy KW, Wang CC, Ogura A, et al. (2007). "Genomic annotation of 15,809 ESTs identified from pooled early gestation human eyes". Physiol. Genomics. 25 (1): 9–15. doi:10.1152/physiolgenomics.00121.2005. PMID 16368877.