Mitochondrial ribosomal protein L13

Mitochondrial ribosomal protein L13 is a protein that in humans is encoded by the MRPL13 gene.

MRPL13
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3J7Y, 3J9M
Identifiers
Aliases	MRPL13, L13, L13A, L13mt, RPL13, RPML13, mitochondrial ribosomal protein L13
External IDs	OMIM: 610200; MGI: 2137218; HomoloGene: 90894; GeneCards: MRPL13; OMA:MRPL13 - orthologs
Gene location (Human) Chr. Chromosome 8 (human) Band 8q24.12 Start 120,380,761 bp End 120,445,402 bp
Gene location (Mouse) Chr. Chromosome 15 (mouse) Band 15|15 D1 Start 55,397,490 bp End 55,421,144 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of transverse colon ganglionic eminence ventricular zone right adrenal gland right adrenal cortex islet of Langerhans rectum stromal cell of endometrium left adrenal gland left adrenal cortex Top expressed in medial ganglionic eminence maxillary prominence mandibular prominence intercostal muscle Gonadal ridge external carotid artery internal carotid artery right ventricle fetal liver hematopoietic progenitor cell digastric muscle More reference expression data BioGPS n/a
Gene ontology Molecular function structural constituent of ribosome protein binding mRNA binding RNA binding Cellular component mitochondrial inner membrane ribosome mitochondrial ribosome mitochondrion mitochondrial large ribosomal subunit Biological process mitochondrial translational elongation mitochondrial translational termination protein biosynthesis negative regulation of translation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 28998 68537 Ensembl ENSG00000172172 ENSMUSG00000022370 UniProt Q9BYD1 Q9D1P0 RefSeq (mRNA) NM_014078 NM_026759 RefSeq (protein) NP_054797 NP_081035 Location (UCSC) Chr 8: 120.38 – 120.45 Mb Chr 15: 55.4 – 55.42 Mb PubMed search
Wikidata
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Function

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and play a crucial role in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) are composed of a small 28S subunit and a large 39S subunit, with an estimated protein to rRNA composition of 75% with contrasts with prokaryotic ribosomes, where this ratio is reversed. Another distinction between mammalian mitoribosomes and prokaryotic ribosomes is that the latter includes a 5S rRNA. The proteins that make up the mitoribosome vary significantly in sequence, and sometimes in biochemical properties across different species, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein.

Further reading

• Mukhopadhyay R, Ray PS, Arif A, Brady AK, Kinter M, Fox PL (2008). "DAPK-ZIPK-L13a axis constitutes a negative-feedback module regulating inflammatory gene expression". Mol. Cell. 32 (3): 371–82. doi:10.1016/j.molcel.2008.09.019. PMC 2644327. PMID 18995835.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.