Mitochondrial ribosomal protein L4

39S ribosomal protein L4, mitochondrial is a protein that in humans is encoded by the MRPL4 gene.

MRPL4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3J7Y, 3J9M,%%s3J7Y, 3J9M
Identifiers
Aliases	MRPL4, CGI-28, L4mt, mitochondrial ribosomal protein L4
External IDs	OMIM: 611823; MGI: 2137210; HomoloGene: 32286; GeneCards: MRPL4; OMA:MRPL4 - orthologs
Gene location (Human) Chr. Chromosome 19 (human) Band 19p13.2 Start 10,251,901 bp End 10,260,055 bp
Gene location (Mouse) Chr. Chromosome 9 (mouse) Band 9|9 A3 Start 20,914,034 bp End 20,920,135 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in apex of heart mucosa of transverse colon right auricle right adrenal gland left adrenal gland right adrenal cortex right lobe of liver left ventricle left adrenal cortex skin of abdomen Top expressed in interventricular septum right kidney myocardium of ventricle right ventricle extensor digitorum longus muscle cardiac muscle tissue of left ventricle brown adipose tissue internal carotid artery adrenal gland external carotid artery More reference expression data BioGPS More reference expression data
Gene ontology Molecular function structural constituent of ribosome protein binding RNA binding Cellular component mitochondrial inner membrane ribosome mitochondrion cytosolic ribosome mitochondrial large ribosomal subunit Biological process mitochondrial translational elongation mitochondrial translational termination protein biosynthesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51073 66163 Ensembl ENSG00000105364 ENSMUSG00000003299 UniProt Q9BYD3 Q9DCU6 RefSeq (mRNA) NM_015956 NM_146387 NM_146388 NM_023167 NM_001357899 RefSeq (protein) NP_057040 NP_666499 NP_666500 NP_057040.2 NP_666499.1 NP_075656 NP_001344828 Location (UCSC) Chr 19: 10.25 – 10.26 Mb Chr 9: 20.91 – 20.92 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Sequence analysis identified alternatively spliced variants that encode different protein isoforms.

Further reading

• Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
• Yu W, Andersson B, Worley KC, et al. (1997). "Large-Scale Concatenation cDNA Sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
• Lai CH, Chou CY, Ch'ang LY, et al. (2000). "Identification of Novel Human Genes Evolutionarily Conserved in Caenorhabditis elegans by Comparative Proteomics". Genome Res. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC 310876. PMID 10810093.
• Suzuki T, Terasaki M, Takemoto-Hori C, et al. (2001). "Structural compensation for the deficit of rRNA with proteins in the mammalian mitochondrial ribosome. Systematic analysis of protein components of the large ribosomal subunit from mammalian mitochondria". J. Biol. Chem. 276 (24): 21724–36. doi:10.1074/jbc.M100432200. PMID 11279069.
• Kenmochi N, Suzuki T, Uechi T, et al. (2001). "The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders". Genomics. 77 (1–2): 65–70. doi:10.1006/geno.2001.6622. PMID 11543634.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Zhang Z, Gerstein M (2003). "Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome". Genomics. 81 (5): 468–80. doi:10.1016/S0888-7543(03)00004-1. PMID 12706105.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

External links

• Overview of all the structural information available in the PDB for UniProt: Q9BYD3 (39S ribosomal protein L4, mitochondrial) at the PDBe-KB.