Musashi-1

RNA-binding protein Musashi homolog 1 also known as Musashi-1 is a protein that in humans is encoded by the MSI1 gene.

MSI1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1UAW, 2MSS, 2MST, 2RS2
Identifiers
Aliases	MSI1, musashi RNA binding protein 1
External IDs	OMIM: 603328; MGI: 107376; HomoloGene: 55657; GeneCards: MSI1; OMA:MSI1 - orthologs
Gene location (Human) Chr. Chromosome 12 (human) Band 12q24.31 Start 120,341,330 bp End 120,369,164 bp
Gene location (Mouse) Chr. Chromosome 5 (mouse) Band 5|5 F Start 115,567,658 bp End 115,593,757 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone ganglionic eminence frontal pole left testis right testis anterior pituitary islet of Langerhans amygdala cingulate gyrus anterior cingulate cortex Top expressed in neural layer of retina ventricular zone molar epithelium of lens Rostral migratory stream ganglionic eminence tail of embryo habenula epiblast somite More reference expression data BioGPS More reference expression data
Gene ontology Molecular function single-stranded RNA binding nucleic acid binding poly(U) RNA binding identical protein binding RNA binding Cellular component cytoplasm polysome nucleus ribonucleoprotein complex Biological process nervous system development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4440 17690 Ensembl ENSG00000135097 ENSMUSG00000054256 UniProt O43347 Q61474 RefSeq (mRNA) NM_002442 NM_008629 NM_001376960 NM_001376961 NM_001376962 NM_001376963 RefSeq (protein) NP_002433 NP_032655 NP_001363889 NP_001363890 NP_001363891 NP_001363892 Location (UCSC) Chr 12: 120.34 – 120.37 Mb Chr 5: 115.57 – 115.59 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene encodes a protein containing two conserved tandem RNA recognition motifs and functions as an RNA binding protein that is involved in post-transcriptional gene editing. It is a stem cell marker that controls the balance between self-renewal and terminal differentiation.

Clinical significance

Over expression of this gene is associated with the grade of the malignancy and proliferative activity in gliomas and melanomas. An increased expression of MSI1 protein is observed in endometriosis and endometrial carcinoma siRNA-mediated inhibition of MSI expression in endometrial carcinoma cells induces apoptosis and inhibits cell proliferation by affecting the Notch signaling pathway

MSI1 is highly expressed in neural progenitor cells and is required for normal development of the brain. A mutation in these gene is responsible for autosomal recessive primary microcephaly. MSI1 also interacts with the Zika virus genome and may explain why these cells are highly susceptible to Zika virus infection.

See also

• Musashi-2

Further reading

• Okano H, Imai T, Okabe M (April 2002). "Musashi: a translational regulator of cell fate". Journal of Cell Science. 115 (Pt 7): 1355–9. doi:10.1242/jcs.115.7.1355. PMID 11896183.
• Toda M, Iizuka Y, Yu W, Imai T, Ikeda E, Yoshida K, Kawase T, Kawakami Y, Okano H, Uyemura K (April 2001). "Expression of the neural RNA-binding protein Musashi1 in human gliomas". Glia. 34 (1): 1–7. doi:10.1002/glia.1034. PMID 11284014. S2CID 24208393.
• Imai T, Tokunaga A, Yoshida T, Hashimoto M, Mikoshiba K, Weinmaster G, Nakafuku M, Okano H (June 2001). "The neural RNA-binding protein Musashi1 translationally regulates mammalian numb gene expression by interacting with its mRNA". Molecular and Cellular Biology. 21 (12): 3888–900. doi:10.1128/MCB.21.12.3888-3900.2001. PMC 87052. PMID 11359897.
• Sakakibara S, Nakamura Y, Satoh H, Okano H (October 2001). "Rna-binding protein Musashi2: developmentally regulated expression in neural precursor cells and subpopulations of neurons in mammalian CNS". The Journal of Neuroscience. 21 (20): 8091–107. doi:10.1523/JNEUROSCI.21-20-08091.2001. PMC 6763847. PMID 11588182.
• Kanemura Y, Mori K, Sakakibara S, Fujikawa H, Hayashi H, Nakano A, Matsumoto T, Tamura K, Imai T, Ohnishi T, Fushiki S, Nakamura Y, Yamasaki M, Okano H, Arita N (September 2001). "Musashi1, an evolutionarily conserved neural RNA-binding protein, is a versatile marker of human glioma cells in determining their cellular origin, malignancy, and proliferative activity". Differentiation; Research in Biological Diversity. 68 (2–3): 141–52. doi:10.1046/j.1432-0436.2001.680208.x. PMID 11686236.
• Kanemura Y, Sakakibara S, Okano H (2002). "Identification of Musashi1-positive cells in human normal and neoplastic neuroepithelial tissues by immunohistochemical methods". Neural Stem Cells. Methods in Molecular Biology. Vol. 198. pp. 273–81. doi:10.1385/1-59259-186-8:273. ISBN 1-59259-186-8. PMID 11951628.
• Shu HJ, Saito T, Watanabe H, Ito JI, Takeda H, Okano H, Kawata S (April 2002). "Expression of the Musashi1 gene encoding the RNA-binding protein in human hepatoma cell lines". Biochemical and Biophysical Research Communications. 293 (1): 150–4. doi:10.1016/S0006-291X(02)00175-4. PMID 12054577.
• Miyanoiri Y, Kobayashi H, Imai T, Watanabe M, Nagata T, Uesugi S, Okano H, Katahira M (October 2003). "Origin of higher affinity to RNA of the N-terminal RNA-binding domain than that of the C-terminal one of a mouse neural protein, musashi1, as revealed by comparison of their structures, modes of interaction, surface electrostatic potentials, and backbone dynamics". The Journal of Biological Chemistry. 278 (42): 41309–15. doi:10.1074/jbc.M306210200. PMID 12907678.
• Nishimura S, Wakabayashi N, Toyoda K, Kashima K, Mitsufuji S (August 2003). "Expression of Musashi-1 in human normal colon crypt cells: a possible stem cell marker of human colon epithelium". Digestive Diseases and Sciences. 48 (8): 1523–9. doi:10.1023/A:1024763723240. PMID 12924647. S2CID 27912813.
• Lovell MA, Markesbery WR (August 2005). "Ectopic expression of Musashi-1 in Alzheimer disease and Pick disease". Journal of Neuropathology and Experimental Neurology. 64 (8): 675–80. doi:10.1097/01.jnen.0000173891.17176.5b. PMID 16106215. S2CID 16906563.
• Battelli C, Nikopoulos GN, Mitchell JG, Verdi JM (January 2006). "The RNA-binding protein Musashi-1 regulates neural development through the translational repression of p21WAF-1". Molecular and Cellular Neurosciences. 31 (1): 85–96. doi:10.1016/j.mcn.2005.09.003. PMID 16214366. S2CID 11496642.
• Chan C, Moore BE, Cotman CW, Okano H, Tavares R, Hovanesian V, Pinar H, Johanson CE, Svendsen CN, Stopa EG (October 2006). "Musashi1 antigen expression in human fetal germinal matrix development". Experimental Neurology. 201 (2): 515–8. doi:10.1016/j.expneurol.2006.04.023. PMID 16777095. S2CID 26877499.