Mucin 17

Mucin-17 is a protein that in humans is encoded by the MUC17 gene.

MUC17
Identifiers
Aliases	MUC17, MUC3, MUC-17, MUC-3, mucin 17, cell surface associated
External IDs	OMIM: 608424; HomoloGene: 134646; GeneCards: MUC17; OMA:MUC17 - orthologs
Gene location (Human) Chr. Chromosome 7 (human) Band 7q22.1 Start 101,020,072 bp End 101,058,859 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in duodenum rectum testicle transverse colon right lobe of liver smooth muscle tissue appendix sural nerve islet of Langerhans right lung n/a More reference expression data BioGPS n/a
Gene ontology Molecular function PDZ domain binding extracellular matrix constituent, lubricant activity protein binding Cellular component Golgi lumen integral component of membrane extracellular region membrane external side of plasma membrane apical plasma membrane plasma membrane collagen-containing extracellular matrix Biological process cellular homeostasis O-glycan processing stimulatory C-type lectin receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 140453 n/a Ensembl ENSG00000169876 n/a UniProt Q685J3 n/a RefSeq (mRNA) NM_001004430 NM_001040105 n/a RefSeq (protein) NP_001035194 n/a Location (UCSC) Chr 7: 101.02 – 101.06 Mb n/a PubMed search n/a
Wikidata
View/Edit Human

Membrane mucins, such as MUC17, function in epithelial cells to provide cytoprotection, maintain luminal structure, provide signal transduction, and confer antiadhesive properties upon cancer cells that lose their apical/basal polarization.[supplied by OMIM]

Further reading

• Kitamoto S, Yamada N, Yokoyama S, et al. (2011). "DNA methylation and histone H3-K9 modifications contribute to MUC17 expression". Glycobiology. 21 (2): 247–56. doi:10.1093/glycob/cwq155. PMC 3010767. PMID 20926598.
• Malmberg EK, Pelaseyed T, Petersson AC, et al. (2008). "The C-terminus of the transmembrane mucin MUC17 binds to the scaffold protein PDZK1 that stably localizes it to the enterocyte apical membrane in the small intestine" (PDF). Biochem. J. 410 (2): 283–9. doi:10.1042/BJ20071068. PMID 17990980. S2CID 207870.
• Moniaux N, Junker WM, Singh AP, et al. (2006). "Characterization of human mucin MUC17. Complete coding sequence and organization". J. Biol. Chem. 281 (33): 23676–23685. doi:10.1074/jbc.M600302200. PMID 16737958.
• Oh JH, Yang JO, Hahn Y, et al. (2006). "Transcriptome analysis of human gastric cancer". Mamm. Genome. 16 (12): 942–954. doi:10.1007/s00335-005-0075-2. PMID 16341674. S2CID 69278.
• Ho JJ, Jaituni RS, Crawley SC, et al. (2004). "N-glycosylation is required for the surface localization of MUC17 mucin". Int. J. Oncol. 23 (3): 585–92. doi:10.3892/ijo.23.3.585. PMID 12888891.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Wang R, Khatri IA, Forstner JF (2002). "C-terminal domain of rodent intestinal mucin Muc3 is proteolytically cleaved in the endoplasmic reticulum to generate extracellular and membrane components". Biochem. J. 366 (Pt 2): 623–31. doi:10.1042/BJ20020289. PMC 1222797. PMID 12027806.
• Van Klinken BJ, Van Dijken TC, Oussoren E, et al. (1997). "Molecular cloning of human MUC3 cDNA reveals a novel 59 amino acid tandem repeat region". Biochem. Biophys. Res. Commun. 238 (1): 143–148. doi:10.1006/bbrc.1997.7258. PMID 9299468.