Mucin 5AC

MUC5AC
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	5AJN, 5AJP, 5AJO
Identifiers
Aliases	MUC5AC, MUC5, TBM, leB, mucin, mucin 5AC, oligomeric mucus/gel-forming
External IDs	OMIM: 158373; MGI: 104697; HomoloGene: 137237; GeneCards: MUC5AC; OMA:MUC5AC - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	1,201,138 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	141,372,968 bp
RNA expression pattern
	Top expressed in
	olfactory zone of nasal mucosa; ; gastric mucosa; ; body of stomach; ; fundus; ; gallbladder; ; canal of the cervix; ; islet of Langerhans; ; appendix; ; urinary bladder; ; muscle tissue;
	Top expressed in
	pyloric antrum; ; epithelium of stomach; ; mucous cell of stomach; ; conjunctival fornix; ; duodenum; ; olfactory epithelium; ; quadriceps femoris muscle; ; esophagus; ; cornea; ; pancreas;
	More reference expression data
	n/a
Gene ontology
Molecular function	extracellular matrix structural constituent;
Cellular component	cytoplasm; Golgi lumen; extracellular region; extracellular exosome; extracellular space; plasma membrane; mucus layer;
Biological process	phosphatidylinositol-mediated signaling; O-glycan processing; stimulatory C-type lectin receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	4586
	17833
	ENSG00000215182; ENSG00000283158
	ENSMUSG00000037974
	P98088
	n/a
	NM_017511; NM_001304359
	NM_010844
	NP_001291288
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Mucin-5AC (MUC-5AC) is a protein that is encoded by the MUC5AC gene in humans.^[5]^[6]^[7]

MUC-5AC is a large gel-forming glycoprotein. In the respiratory tract, it protects against infection by binding to inhaled pathogens, which are subsequently removed by mucociliary clearance. Overproduction of MUC-5AC can contribute to diseases such as asthma and chronic obstructive pulmonary disease,^[8] and has also been associated with greater protection against influenza infection.^[9]

Clinical relevance

This gene has been linked to mucus hypersecretion in the respiratory tract and is associated to chronic obstructive pulmonary disease (COPD).^[10]

References

^ ^a ^b ^c ENSG00000283158 GRCh38: Ensembl release 89: ENSG00000215182, ENSG00000283158 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000037974 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Guyonnet Duperat V, Audie JP, Debailleul V, Laine A, Buisine MP, Galiegue-Zouitina S, Pigny P, Degand P, Aubert JP, Porchet N (Feb 1995). "Characterization of the human mucin gene MUC5AC: a consensus cysteine-rich domain for 11p15 mucin genes?". Biochem J. 305 (Pt 1): 211–9. doi:10.1042/bj3050211. PMC 1136451. PMID 7826332.
^ van de Bovenkamp JH, Hau CM, Strous GJ, Buller HA, Dekker J, Einerhand AW (Jun 1998). "Molecular cloning of human gastric mucin MUC5AC reveals conserved cysteine-rich D-domains and a putative leucine zipper motif". Biochem Biophys Res Commun. 245 (3): 853–9. doi:10.1006/bbrc.1998.8535. PMID 9588204.
^ "Entrez Gene: MUC5AC mucin 5AC, oligomeric mucus/gel-forming".
^ Samsuzzaman M, Uddin MS, Shah MA, Mathew B (August 2019). "Natural inhibitors on airway mucin: Molecular insight into the therapeutic potential targeting MUC5AC expression and production". Life Sciences. 231: 116485. doi:10.1016/j.lfs.2019.05.041. PMID 31116959. S2CID 162182150.
^ Ehre C, Worthington EN, Liesman RM, Grubb BR, Barbier D, O'Neal WK, Sallenave JM, Pickles RJ, Boucher RC (2012-10-09). "Overexpressing mouse model demonstrates the protective role of Muc5ac in the lungs". Proceedings of the National Academy of Sciences of the United States of America. 109 (41): 16528–16533. Bibcode:2012PNAS..10916528E. doi:10.1073/pnas.1206552109. ISSN 1091-6490. PMC 3478656. PMID 23012413.
^ Li J, Ye Z (September 2020). "The Potential Role and Regulatory Mechanisms of MUC5AC in Chronic Obstructive Pulmonary Disease". Molecules. 25 (19). Basel, Switzerland: 4437. doi:10.3390/molecules25194437. PMC 7582261. PMID 32992527.

External links

PDBe-KB provides an overview of all the structure information available in the PDB for Human Mucin-5AC

This protein-related article is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] ENSG00000283158 GRCh38: Ensembl release 89: ENSG00000215182, ENSG00000283158 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000037974 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7826332-5] Guyonnet Duperat V, Audie JP, Debailleul V, Laine A, Buisine MP, Galiegue-Zouitina S, Pigny P, Degand P, Aubert JP, Porchet N (Feb 1995). "Characterization of the human mucin gene MUC5AC: a consensus cysteine-rich domain for 11p15 mucin genes?". Biochem J. 305 (Pt 1): 211–9. doi:10.1042/bj3050211. PMC 1136451. PMID 7826332.

[pmid9588204-6] van de Bovenkamp JH, Hau CM, Strous GJ, Buller HA, Dekker J, Einerhand AW (Jun 1998). "Molecular cloning of human gastric mucin MUC5AC reveals conserved cysteine-rich D-domains and a putative leucine zipper motif". Biochem Biophys Res Commun. 245 (3): 853–9. doi:10.1006/bbrc.1998.8535. PMID 9588204.

[7] "Entrez Gene: MUC5AC mucin 5AC, oligomeric mucus/gel-forming".

[Samsuzzaman_2019-8] Samsuzzaman M, Uddin MS, Shah MA, Mathew B (August 2019). "Natural inhibitors on airway mucin: Molecular insight into the therapeutic potential targeting MUC5AC expression and production". Life Sciences. 231: 116485. doi:10.1016/j.lfs.2019.05.041. PMID 31116959. S2CID 162182150.

[9] Ehre C, Worthington EN, Liesman RM, Grubb BR, Barbier D, O'Neal WK, Sallenave JM, Pickles RJ, Boucher RC (2012-10-09). "Overexpressing mouse model demonstrates the protective role of Muc5ac in the lungs". Proceedings of the National Academy of Sciences of the United States of America. 109 (41): 16528–16533. Bibcode:2012PNAS..10916528E. doi:10.1073/pnas.1206552109. ISSN 1091-6490. PMC 3478656. PMID 23012413.

[pmid32992527-10] Li J, Ye Z (September 2020). "The Potential Role and Regulatory Mechanisms of MUC5AC in Chronic Obstructive Pulmonary Disease". Molecules. 25 (19). Basel, Switzerland: 4437. doi:10.3390/molecules25194437. PMC 7582261. PMID 32992527.

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