Macarius II or Makarios II may refer to:
- Pope Macarius II of Alexandria (d. 1128), Coptic leader
- Macarius II of Antioch (r. 1164–1166), Greek Orthodox patriarch of Antioch
- Makarios II of Cyprus (d. 1950), archbishop
- Macarius (Nevsky) (r. 1912–1917), metropolitan of Moscow
This disambiguation page lists articles about people with the same name.
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