Manuel Álvarez may refer to:
- Manuel Francisco Álvarez de la Peña (1727–1797), Spanish sculptor
- Manny Alvarez (born c. 1957), Cuban-American ob-gyn
- Manuel Álvarez (sprinter) (1910–1991), Mexican sprinter who competed in the 1932 Summer Olympics
- Manuel Álvarez (trader) (1794–1856), trader and later politician in Santa Fe, New Mexico
- Manuel Álvarez Bravo (1902–2002), Mexican photographer
- Manuel Álvarez (footballer) (1928–1998), Chile football defender who played for Chile in the 1950 FIFA World Cup
- José Manuel Álvarez, Governor of Córdoba, Argentina, 1901–1904
- Juan Manuel Álvarez (born 1979), Californian convicted of causing the 2005 Glendale train crash