Maria Antonia may refer to:
- Maria Antonia of Austria (1669–1692) daughter of Leopold I, Holy Roman Emperor and Margarita Teresa of Austria
- Maria Antonia Pereira (1700–1760), Spanish founder of the carmelite convent of Santiago de Compostela.
- Duchess Maria Antonia of Bavaria (1724–1780) daughter of Charles VII, Holy Roman Emperor and Maria Amalia of Austria
- Maria Antonia Ferdinanda of Spain (1729–1785) daughter of Philip V of Spain and Elisabetta Farnese
- Maria Antonia Josepha Johanna of Austria, birthname of Marie Antoinette, (1755–1793) daughter of Francis I, Holy Roman Emperor and Empress Maria Theresa
- Countess Maria Antonia of Waldstein-Wartenberg (1771–1854) mother of Maria Antonia Koháry de Csábrág
- Princess Maria Antonia of Parma (1774–1841) daughter of Ferdinand I of Parma and Maria Amalia of Austria
- Princess Maria Antonia of Naples and Sicily (1784–1806) daughter of Ferdinand I of the Two Sicilies and Maria Carolina of Austria
- Princess Maria Antonia Koháry (1797–1862) daughter of Ferencz József Koháry de Csábrág and Maria Antonia of Waldstein-Wartenberg
- Princess Maria Antonia of the Two Sicilies (1814–1898) daughter of Francis I of the Two Sicilies and Maria Isabella of Spain
- Archduchess Maria Antonia of Austria (1858–1883) daughter of Ferdinand IV, Grand Duke of Tuscany and Anna of Saxony
- Infanta Maria Antonia of Portugal (1862–1959) daughter of Miguel I of Portugal and Adelaide of Löwenstein-Wertheim-Rosenberg
- Maria Antonia of Austria (1874–1891) daughter of Archduke Karl Salvator of Austria and Maria Immaculata of Bourbon-Two Sicilies
- Maria Antonia of the Two Sicilies (1898–1957) daughter of Prince Ferdinand Pius, Duke of Calabria and Princess Maria Ludwiga Theresia of Bavaria
- Archduchess Maria Antonia of Austria (1899–1977) daughter of Archduke Leopold Salvator of Austria and Infanta Blanca of Spain
- Maria Antonia Braile (fl. 1917), Italian-arbëreshë writer
- María Antonia García Vidal de Santo Silas or María África Gracia Vidal, the birthnames credited to Maria Montez (1912 – 1951), Dominican actress
- Maria Antónia Teixeira Rosa, birthname of Mia Rose (born 1988), English-born singer-songwriter
- Toña Is, María Antonia Is Piñera (born 1966), Spanish football manager and former player