Maria Medina may refer to:
- Maria Medina (Viganò), an Austrian ballet dancer
- Maria Medina (archer), Puerto Rican archer
- Maria Medina Coeli (1764–1846), Italian scientist
- María Elena Medina-Mora Icaza (born 1951), Mexican psychologist and researcher
- Maria do Carmo Medina, Portuguese-born Angolan human rights defender