Mark Bryant may refer to:
- Mark Bryant (basketball) (born 1965), American professional basketball player and coach
- Mark Bryant (bishop) (born 1949), Church of England bishop
- Mark Bryant (cartoons) (born 1953), British historian of cartoons
- Mark Bryant (politician) (born 1956), American politician
- Mark Bryant (rugby league) (born 1981), professional rugby league player
- Mark Bryant (soccer), American retired soccer defender