Mary MacKillop College may refer to:
- Mary MacKillop Catholic Regional College, Leongatha, Victoria
- Mary MacKillop College, Brisbane, a member of the Catholic Secondary Schoolgirls' Sports Association
- Mary MacKillop College, Kensington, Adelaide, South Australia
- Mary MacKillop College, Wakeley, Sydney, New South Wales
- St Mary MacKillop College, Albury
- St Mary MacKillop College, Canberra