ME2 or ME-2 may refer to:
- ME2 (gene)
- "Me²", an episode of the British sitcom Red Dwarf
- Mass Effect 2, a video game released for Microsoft Windows and Xbox 360 in 2010, and for PlayStation 3 in 2011
- Maine's 2nd congressional district
- U.S. Route 2 in Maine
- Me1 vs Me2 Snooker with Richard Herring
- Me Two, French film
See also
edit- Me Too (disambiguation)
- MeetU, web collaboration software by PolyCom
- Mewtwo, a Pokémon
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