(+)-Menthofuran synthase (EC 1.14.13.104, menthofuran synthase, (+)-pulegone 9-hydroxylase, (+)-MFS, cytochrome P450 menthofuran synthase) is an enzyme with systematic name (+)-pulegone,NADPH:oxygen oxidoreductase (9-hydroxylating).[1][2] This enzyme catalyses the following chemical reaction
| (+)-Menthofuran synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
-menthofuran_synthase_reaction.PNG) | |||||||||
| Identifiers | |||||||||
| EC no. | 1.14.13.104 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
- (+)-pulegone + NADPH + H+ + O2 (+)-menthofuran + NADP+ + H2O
References
edit- ^ Bertea CM, Schalk M, Karp F, Maffei M, Croteau R (June 2001). "Demonstration that menthofuran synthase of mint (Mentha) is a cytochrome P450 monooxygenase: cloning, functional expression, and characterization of the responsible gene". Archives of Biochemistry and Biophysics. 390 (2): 279–86. doi:10.1006/abbi.2001.2378. PMID 11396930.
- ^ Mahmoud SS, Croteau RB (November 2003). "Menthofuran regulates essential oil biosynthesis in peppermint by controlling a downstream monoterpene reductase". Proceedings of the National Academy of Sciences of the United States of America. 100 (24): 14481–6. Bibcode:2003PNAS..10014481M. doi:10.1073/pnas.2436325100. PMC 283617. PMID 14623962.
External links
edit- (+)-menthofuran+synthase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
