Mentzen is a surname. Notable people with the name include:
- Antje Tesche-Mentzen , German painter
- Frédéric Mentzen, composer; see Alone in the Dark 3
- Mieczysław Mentzen , Polish mathematician
- Sławomir Mentzen, Polish politician and leader of the Confederation Liberty and Independence
- Raphael Mentzen, trumpet player, see Release the Stars