Michael O'Keefe (born 1955) is an American film and television actor.
Michael O'Keefe or O'Keeffe may also refer to;
- Michael A. O'Keefe (born 1942), Australian physicist
- Michael Kenny O'Keefe (born 1963), American judge on the D.C. Superior Court
- Michael O'Keeffe (footballer) (born 1990), New Zealand footballer
- Michael O'Keeffe (chemist) (born 1934), American crystallographer
- Michael O'Keefe (Tasmanian politician) (1864–1926), Australian politician in Tasmania
- Michael O'Keefe (Louisiana politician) (1932–2021), American politician in Louisiana
- Michael O'Keeffe (Queensland politician) (1854–1941), Australian politician in Queensland
- Michael O'Keeffe (Irish-American grocer) (1866–1931), co-founder and first president of First National Stores
See also
edit- Miles O'Keeffe (born 1954), American movie star of the 1980s
- Michael Edwin Keefe (1844–1933), Nova Scotia politician
- Michael Keith (disambiguation)