MicroRNA 7-2

MIR7-2
Identifiers
Aliases	MIR7-2, MIRN7-2, hsa-mir-7-2, mir-7-2, microRNA 7-2
External IDs	GeneCards: MIR7-2; OMA:MIR7-2 - orthologs
Gene location (Human)
Chr.	Chromosome 15 (human)
End	88,611,934 bp
RNA expression pattern
	Top expressed in
	monocyte; ; blood; ; tibial arteries; ; hippocampus proper; ; mucosa of esophagus; ; right ovary; ; lung; ; spleen; ; thyroid gland; ; left lobe of thyroid gland;
	n/a
	More reference expression data
	n/a
Orthologs
	407044
	n/a
	ENSG00000207703
	n/a
	n; a
	n/a
	n/a
	n/a
	n/a
	n/a
	Wikidata
View/Edit Human

MicroRNA 7-2 is a non-protein-coding gene product that in humans is encoded by the MIR7-2 gene. ^[3]

Function

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000207703 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: MicroRNA 7-2". Retrieved 2016-09-18.

MicroRNA 7-2

Function

References

Further reading