MAP1B

Microtubule-associated protein 1B is a protein that in humans is encoded by the MAP1B gene.

MAP1B
Identifiers
Aliases	MAP1B, FUTSCH, MAP5, PPP1R102, microtubule-associated protein 1B, microtubule associated protein 1B, PVNH9, DFNA83
External IDs	OMIM: 157129; MGI: 1306778; HomoloGene: 38111; GeneCards: MAP1B; OMA:MAP1B - orthologs
Gene location (Human) Chr. Chromosome 5 (human) Band 5q13.2 Start 72,107,234 bp End 72,209,565 bp
Gene location (Mouse) Chr. Chromosome 13 (mouse) Band 13 D1|13 52.9 cM Start 99,557,954 bp End 99,653,048 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in lateral nuclear group of thalamus pars compacta middle temporal gyrus pars reticulata Brodmann area 23 superior vestibular nucleus pons external globus pallidus parietal lobe postcentral gyrus Top expressed in facial motor nucleus anterior horn of spinal cord median eminence substantia nigra medial dorsal nucleus habenula medial vestibular nucleus Rostral migratory stream pontine nuclei medial geniculate nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function microtubule binding structural molecule activity protein binding actin binding tubulin binding phospholipid binding protein-containing complex binding Cellular component cell projection postsynaptic density plasma membrane dendritic spine photoreceptor outer segment synapse microtubule associated complex cell junction microtubule cytoskeleton cytoplasm cytosol axon dendrite somatodendritic compartment soma apical dendrite basal dendrite hippocampal mossy fiber growth cone varicosity perikaryon perinuclear region of cytoplasm Biological process negative regulation of intracellular transport axonogenesis dendrite development nervous system development microtubule bundle formation axon extension positive regulation of axon extension mitochondrion transport along microtubule establishment of monopolar cell polarity cellular process microtubule cytoskeleton organization neuron migration regulation of microtubule depolymerization negative regulation of microtubule depolymerization synapse assembly response to wounding response to mechanical stimulus response to carbohydrate response to inorganic substance peripheral nervous system axon regeneration response to insecticide developmental maturation positive regulation of microtubule polymerization response to nutrient levels response to estradiol response to vitamin A positive regulation of neuron differentiation neuron development response to axon injury induction of synaptic plasticity by chemical substance cellular response to growth factor stimulus cellular response to peptide hormone stimulus Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4131 17755 Ensembl ENSG00000131711 ENSMUSG00000052727 UniProt P46821 P14873 RefSeq (mRNA) NM_005909 NM_032010 NM_001324255 NM_008634 RefSeq (protein) NP_001311184 NP_005900 NP_032660 Location (UCSC) Chr 5: 72.11 – 72.21 Mb Chr 13: 99.56 – 99.65 Mb PubMed search
Wikidata
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Function

This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The product of this gene is a precursor polypeptide that presumably undergoes proteolytic processing to generate the final MAP1B heavy chain and LC1 light chain. Gene knockout studies of the mouse microtubule-associated protein 1B gene suggested an important role in development and function of the nervous system. Two alternatively spliced transcript variants have been described.

Interactions

MAP1B has been shown to interact with Acidic leucine-rich nuclear phosphoprotein 32 family member A and RASSF1.

Further reading

• Hammarback JA, Obar RA, Hughes SM, Vallee RB (1991). "MAP1B is encoded as a polyprotein that is processed to form a complex N-terminal microtubule-binding domain". Neuron. 7 (1): 129–39. doi:10.1016/0896-6273(91)90081-A. PMID 1712602. S2CID 34690111.
• Schoenfeld TA, McKerracher L, Obar R, Vallee RB (1989). "MAP 1A and MAP 1B are structurally related microtubule associated proteins with distinct developmental patterns in the CNS". J. Neurosci. 9 (5): 1712–30. doi:10.1523/JNEUROSCI.09-05-01712.1989. PMC 6569839. PMID 2470876.
• Avila J, Ulloa L, Diez-Guerra J, Diaz-Nido J (1994). "Role of phosphorylated MAPlB in neuritogenesis". Cell Biol. Int. 18 (5): 309–14. doi:10.1006/cbir.1994.1079. PMID 7519512. S2CID 85789590.
• Lien LL, Feener CA, Fischbach N, Kunkel LM (1994). "Cloning of human microtubule-associated protein 1B and the identification of a related gene on chromosome 15". Genomics. 22 (2): 273–80. doi:10.1006/geno.1994.1384. PMID 7806212.
• Ohyu J, Takashima S (1998). "Decreased expression of microtubule-associated protein 5 (MAP5) in the molecular layer of cerebellum in preterm infants with olivocerebellar lesions". Brain Dev. 20 (1): 22–6. doi:10.1016/S0387-7604(97)00088-0. PMID 9533556. S2CID 20265712.
• Lucas FR, Goold RG, Gordon-Weeks PR, Salinas PC (1998). "Inhibition of GSK-3beta leading to the loss of phosphorylated MAP-1B is an early event in axonal remodelling induced by WNT-7a or lithium". J. Cell Sci. 111 ( Pt 10) (10): 1351–61. doi:10.1242/jcs.111.10.1351. PMID 9570753.
• Tögel M, Wiche G, Propst F (1998). "Novel features of the light chain of microtubule-associated protein MAP1B: microtubule stabilization, self interaction, actin filament binding, and regulation by the heavy chain". J. Cell Biol. 143 (3): 695–707. doi:10.1083/jcb.143.3.695. PMC 2148156. PMID 9813091.
• Hanley JG, Koulen P, Bedford F, Gordon-Weeks PR, Moss SJ (1999). "The protein MAP-1B links GABA(C) receptors to the cytoskeleton at retinal synapses". Nature. 397 (6714): 66–9. Bibcode:1999Natur.397...66H. doi:10.1038/16258. PMID 9892354. S2CID 4421437.
• Jensen PH, Islam K, Kenney J, Nielsen MS, Power J, Gai WP (2000). "Microtubule-associated protein 1B is a component of cortical Lewy bodies and binds alpha-synuclein filaments". J. Biol. Chem. 275 (28): 21500–7. doi:10.1074/jbc.M000099200. PMID 10764738.
• Tanner SL, Franzen R, Jaffe H, Quarles RH (2000). "Evidence for expression of some microtubule-associated protein 1B in neurons as a plasma membrane glycoprotein". J. Neurochem. 75 (2): 553–62. doi:10.1046/j.1471-4159.2000.0750553.x. PMID 10899930. S2CID 33325478.
• Mei X, Sweatt AJ, Hammarback JA (2000). "Regulation of microtubule-associated protein 1B (MAP1B) subunit composition". J. Neurosci. Res. 62 (1): 56–64. doi:10.1002/1097-4547(20001001)62:1<56::AID-JNR6>3.0.CO;2-#. PMID 11002287. S2CID 196600490.
• Billups D, Hanley JG, Orme M, Attwell D, Moss SJ (2000). "GABAC receptor sensitivity is modulated by interaction with MAP1B". J. Neurosci. 20 (23): 8643–50. doi:10.1523/JNEUROSCI.20-23-08643.2000. PMC 6773065. PMID 11102469.
• Franzen R, Tanner SL, Dashiell SM, Rottkamp CA, Hammer JA, Quarles RH (2001). "Microtubule-associated protein 1B: a neuronal binding partner for myelin-associated glycoprotein". J. Cell Biol. 155 (6): 893–8. doi:10.1083/jcb.200108137. PMC 2150906. PMID 11733546.
• Ding J, Liu JJ, Kowal AS, Nardine T, Bhattacharya P, Lee A, Yang Y (2002). "Microtubule-associated protein 1B: a neuronal binding partner for gigaxonin". J. Cell Biol. 158 (3): 427–33. doi:10.1083/jcb.200202055. PMC 2173828. PMID 12147674.
• Dergunova LV, Raevskaya NM, Vladychenskaya IP, Limborska SA (2003). "Hmob3 brain-specific sequence is a part of phylogenetically conserved human MAP1B gene 3'-untranslated region". Biomol. Eng. 20 (3): 91–6. doi:10.1016/S1389-0344(03)00003-0. PMID 12684070.
• Chang L, Jones Y, Ellisman MH, Goldstein LS, Karin M (2003). "JNK1 is required for maintenance of neuronal microtubules and controls phosphorylation of microtubule-associated proteins". Dev. Cell. 4 (4): 521–33. doi:10.1016/S1534-5807(03)00094-7. PMID 12689591.
• Opal P, Garcia JJ, Propst F, Matilla A, Orr HT, Zoghbi HY (2003). "Mapmodulin/leucine-rich acidic nuclear protein binds the light chain of microtubule-associated protein 1B and modulates neuritogenesis". J. Biol. Chem. 278 (36): 34691–9. doi:10.1074/jbc.M302785200. PMID 12807913.