Middletown is the name of more than one location in the U.S. state of Pennsylvania:
- Middletown, Dauphin County, Pennsylvania of the Harrisburg metropolitan area, zip code 17057
- Middletown, Northampton County, Pennsylvania, zip code 18017
- Middletown Township, Bucks County, Pennsylvania, zip code 19047
- Middletown Township, Delaware County, Pennsylvania, zip code 19063
- Middletown Township, Susquehanna County, Pennsylvania
- Middletown, McKean County, Pennsylvania, on Pennsylvania Route 646