Mikhail Mikhaylov or Mikhail Mikhailov is the name of:
- Mikhail Mikhailov (writer) (1829–1865), Russian writer
- Mikhail Mikhaylov (tenor) (1858–1929), Russian opera singer (tenor)
- Mikhail Efimovich Mikhailov (1902–1938), a Soviet central committee member
- Mykhaylo Mykhaylov (born 1959), Soviet Ukrainian footballer
- Mikhail Mikhailov (basketball) (born 1971), Russian basketball player
- Mikhail Mikhaylov (footballer) (born 1981), Russian footballer