Minamestane

Minamestane
Clinical data
ATC code	None;
Identifiers
	IUPAC name 4-aminoandrosta-1,4,6-triene-3,17-dione;
CAS Number	105051-87-4;
PubChem CID	65886;
ChemSpider	59295;
UNII	J02058ABVE;
CompTox Dashboard (EPA)	DTXSID40883152 ;
Chemical and physical data
Formula	C19H23NO2
Molar mass	297.398 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C4\C=C/[C@]3(C(/C=C\[C@H]2[C@H]1[C@@](C(=O)CC1)(CC[C@@H]23)C)=C4/N)C;
	InChI InChI=1S/C19H23NO2/c1-18-10-8-15(21)17(20)14(18)4-3-11-12-5-6-16(22)19(12,2)9-7-13(11)18/h3-4,8,10-13H,5-7,9,20H2,1-2H3/t11-,12-,13-,18+,19-/m0/s1; Key:DAKHYLIFCYPHQW-KZQROQTASA-N;

Minamestane (INN (former developmental code name FCE-24,928) is a steroidal aromatase inhibitor which was under development by Farmitalia-Carlo Erba as an antineoplastic agent in the mid-1990s but was never marketed.^[1]^[2]^[3]

Unlike other steroidal aromatase inhibitors such as formestane and exemestane, minamestane does not have androgenic properties.^[2]

References

^ F.. Macdonald (1997). Dictionary of Pharmacological Agents. CRC Press. p. 1357. ISBN 978-0-412-46630-4. Retrieved 20 May 2012.
^ ^a ^b Di Salle E, Briatico G, Giudici D, et al. (June 1994). "Novel aromatase and 5 alpha-reductase inhibitors". The Journal of Steroid Biochemistry and Molecular Biology. 49 (4–6): 289–94. doi:10.1016/0960-0760(94)90270-4. PMID 8043491. S2CID 54350143.
^ Combs, Donald W (1995). "Review Oncologic, Endocrine & Metabolic: Recent developments in aromatase inhibitors". Expert Opinion on Therapeutic Patents. 5 (6): 529533. doi:10.1517/13543776.5.6.529. ISSN 1354-3776.

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Clinical data

ATC code	None
Identifiers
IUPAC name 4-aminoandrosta-1,4,6-triene-3,17-dione
CAS Number	105051-87-4
PubChem CID	65886
ChemSpider	59295
UNII	J02058ABVE
CompTox Dashboard (EPA)	DTXSID40883152
Chemical and physical data
Formula	C₁₉H₂₃NO₂
Molar mass	297.398 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES O=C4\C=C/[C@]3(C(/C=C\[C@H]2[C@H]1[C@@](C(=O)CC1)(CC[C@@H]23)C)=C4/N)C
InChI InChI=1S/C19H23NO2/c1-18-10-8-15(21)17(20)14(18)4-3-11-12-5-6-16(22)19(12,2)9-7-13(11)18/h3-4,8,10-13H,5-7,9,20H2,1-2H3/t11-,12-,13-,18+,19-/m0/s1 Key:DAKHYLIFCYPHQW-KZQROQTASA-N