Monoamine-depleting agents are a group of drugs which reversibly deplete one or more of the monoamine neurotransmitters – serotonin, dopamine, and norepinephrine.[1][2] One mechanism by which these agents act is by inhibiting reuptake by the vesicular monoamine transporters, VMAT1 and VMAT2.[2][3] Examples of monoamine-depleting agents include deutetrabenazine, oxypertine, reserpine, tetrabenazine, and valbenazine.[1][2][3] Tetrabenazine selectively depletes dopamine at low doses and is used as an animal model of amotivation.[4][5]
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- ^ a b c Vijayakumar D, Jankovic J (May 2016). "Drug-Induced Dyskinesia, Part 2: Treatment of Tardive Dyskinesia". Drugs. 76 (7): 779–87. doi:10.1007/s40265-016-0568-1. PMID 27091214. S2CID 13570794.
- ^ a b Guay DR (August 2010). "Tetrabenazine, a monoamine-depleting drug used in the treatment of hyperkinetic movement disorders". Am J Geriatr Pharmacother. 8 (4): 331–73. doi:10.1016/j.amjopharm.2010.08.006. PMID 20869622.
- ^ Callaghan CK, Rouine J, O'Mara SM (2018). "Potential roles for opioid receptors in motivation and major depressive disorder". Prog Brain Res. 239: 89–119. doi:10.1016/bs.pbr.2018.07.009. PMID 30314570.
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