Mount Jefferson may refer to:
- List of peaks named Mount Jefferson
- Mount Jefferson (Bitterroot Range), mountain in both Fremont County, Idaho and Beaverhead County, Montana
- Mount Jefferson (Massachusetts)
- Mount Jefferson (Maine)
- Mount Jefferson (Madison County, Montana)
- Mount Jefferson (North Carolina)
- Mount Jefferson (New Hampshire)
- Mount Jefferson (Nevada)
- Mount Jefferson (New York)
- Mount Jefferson (Oregon)
- Mount Jefferson (Virginia)
- Mount Jefferson, Ohio, unincorporated community in Loramie Township, Shelby County, Ohio