Mount Vernon High School could refer to:
- Mount Vernon High School (Arkansas)
- Mount Vernon High School (Fortville, Indiana)
- Mount Vernon High School (Mount Vernon, Indiana)
- Mount Vernon High School (Iowa)
- Mount Vernon High School (Missouri)
- Mount Vernon High School (New York)
- Mount Vernon High School (Ohio)
- Mount Vernon High School (South Dakota)
- Mount Vernon High School (Texas)
- Mount Vernon High School (Virginia)
- Mount Vernon High School (Washington)