Murphy Roths large (MRL/MpJ) is a strain of laboratory mouse developed in 1999 at The Wistar Institute in Philadelphia, Pennsylvania.[1] Originally bred for autoimmune disease research, it was discovered to have remarkable tissue regeneration abilities.[2][3][4]
Research
editThe MRL/MpJ mouse strain was selectively bred by scientists to have an autoimmune genetic disorder (retained through inbreeding) to be used as a model for autoimmune disease research.[1] After making puncture wounds in their ears, these mice were observed to completely regenerate from these wounds without development of scar tissue.[1][2] In further research, this mouse strain has been observed to have the ability to also regenerate cardiac tissue, displays a resistance to muscle dystrophy, and is resistant to experiencing hyperglycemia from a diet high in fats.[5][6][7]
References
edit- ^ a b c Clark, Lise Desquenne; Clark, Robert K.; Heber-Katz, Ellen (July 1998). "A New Murine Model for Mammalian Wound Repair and Regeneration". Clinical Immunology and Immunopathology. 88 (1): 35–45. doi:10.1006/clin.1998.4519. ISSN 0090-1229. PMID 9683548. S2CID 3734804.
- ^ a b Heber-Katz, E.; Leferovich, J. M.; Bedelbaeva, K.; Gourevitch, D. (2004). "Spallanzani's Mouse: A Model of Restoration and Regeneration". Regeneration: Stem Cells and Beyond. Current Topics in Microbiology and Immunology. Vol. 280. pp. 165–89. doi:10.1007/978-3-642-18846-6_5. ISBN 978-3-642-62321-9. PMID 14594211.
- ^ Morelle, Rebecca (11 April 2006). "Mouse sheds light on regeneration". BBC News.
- ^ Carswell, Lindsay (18 April 2006). "Self-healing Mice". ScienCentral News. Archived from the original on 20 October 2008.
- ^ Heber-Katz, Ellen; Leferovich, John M.; Bedelbaeva, Khamilia (2001-12-01). "Spontaneous heart regeneration in adult MRL mice after cryoinjury". Gene Therapy and Regulation. 1 (4): 399–407. doi:10.1163/156855801760107055. ISSN 1568-5586.
- ^ Heydemann, Ahlke; Swaggart, Kayleigh; Kim, Gene H; Holley-Cuthrell, Jenan; Hadhazy, Michele; McNally, Elizabeth M (2012). "The superhealing MRL background improves muscular dystrophy". Skeletal Muscle. 2 (1): 26. doi:10.1186/2044-5040-2-26. ISSN 2044-5040. PMC 3534636. PMID 23216833.
- ^ Mull, Aaron J.; Berhanu, Tirsit K.; Roberts, Nathan W.; Heydemann, Ahlke (December 2014). "The Murphy Roths Large (MRL) mouse strain is naturally resistant to high fat diet-induced hyperglycemia". Metabolism. 63 (12): 1577–1586. doi:10.1016/j.metabol.2014.09.007. ISSN 0026-0495. PMC 4252560. PMID 25308446.
External links
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