In enzymology, a N6-acetyl-beta-lysine transaminase (EC 2.6.1.65) is an enzyme that catalyzes the chemical reaction
| N6-acetyl-beta-lysine transaminase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.6.1.65 | ||||||||
| CAS no. | 71768-10-0 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
- 6-acetamido-3-aminohexanoate + 2-oxoglutarate 6-acetamido-3-oxohexanoate + L-glutamate
Thus, the two substrates of this enzyme are 6-acetamido-3-aminohexanoate and 2-oxoglutarate, whereas its two products are 6-acetamido-3-oxohexanoate and L-glutamate.
This enzyme belongs to the family of transferases, specifically the transaminases, which transfer nitrogenous groups. The systematic name of this enzyme class is 6-acetamido-3-aminohexanoate:2-oxoglutarate aminotransferase. This enzyme is also called epsilon-acetyl-beta-lysine aminotransferase. This enzyme participates in lysine degradation. It employs one cofactor, pyridoxal phosphate.
References
edit- Bozler G, Robertson JM, Ohsugi M, Hensley C, Barker HA (1979). "Metabolism of L-beta-lysine in a Pseudomonas: conversion of 6-N-acetyl-L-beta-lysine to 3-keto-6-acetamidohexanoate and of 4-aminobutyrate to succinic semialdehyde by different transaminases". Arch. Biochem. Biophys. 197 (1): 226–35. doi:10.1016/0003-9861(79)90240-6. PMID 44448.
