NFATC1

Nuclear factor of activated T-cells, cytoplasmic 1 is a protein that in humans is encoded by the NFATC1 gene.

NFATC1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1A66, 1NFA
Identifiers
Aliases	NFATC1, NF-ATC, NFAT2, NFATc, NF-ATc1.2, nuclear factor of activated T-cells 1, nuclear factor of activated T cells 1
External IDs	OMIM: 600489; MGI: 102469; HomoloGene: 32336; GeneCards: NFATC1; OMA:NFATC1 - orthologs
Gene location (Human) Chr. Chromosome 18 (human) Band 18q23 Start 79,395,856 bp End 79,529,325 bp
Gene location (Mouse) Chr. Chromosome 18 (mouse) Band 18 E3|18 53.66 cM Start 80,649,420 bp End 80,756,286 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte muscle of thigh secondary oocyte Skeletal muscle tissue of rectus abdominis triceps brachii muscle gastrocnemius muscle Skeletal muscle tissue of biceps brachii sural nerve glutes vastus lateralis muscle Top expressed in granulocyte mesenteric lymph nodes endocardial cushion triceps brachii muscle muscle of thigh olfactory epithelium knee joint temporal muscle blood ankle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA binding RNA polymerase II transcription regulatory region sequence-specific DNA binding DNA-binding transcription factor activity mitogen-activated protein kinase p38 binding FK506 binding DNA-binding transcription activator activity, RNA polymerase II-specific protein binding transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding DNA-binding transcription factor activity, RNA polymerase II-specific chromatin binding transcription factor binding Cellular component cytoplasm cytosol nucleus nucleoplasm nuclear body transcription regulator complex Biological process intracellular signal transduction regulation of transcription, DNA-templated calcineurin-NFAT signaling cascade transcription by RNA polymerase II transcription, DNA-templated positive regulation of transcription, DNA-templated Fc-epsilon receptor signaling pathway positive regulation of transcription by RNA polymerase II Wnt signaling pathway, calcium modulating pathway negative regulation of Wnt signaling pathway negative regulation of vascular associated smooth muscle cell differentiation cytokine production aortic valve morphogenesis pulmonary valve morphogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4772 18018 Ensembl ENSG00000131196 ENSMUSG00000033016 UniProt O95644 O88942 RefSeq (mRNA) NM_172390 NM_001278669 NM_001278670 NM_001278672 NM_001278673 NM_001278675 NM_006162 NM_172387 NM_172388 NM_172389 NM_001164109 NM_001164110 NM_001164111 NM_001164112 NM_016791 NM_198429 RefSeq (protein) NP_001265598 NP_001265599 NP_001265601 NP_001265602 NP_001265604 NP_006153 NP_765975 NP_765976 NP_765977 NP_765978 n/a Location (UCSC) Chr 18: 79.4 – 79.53 Mb Chr 18: 80.65 – 80.76 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Function

The product of this gene is a component of the nuclear factor of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation, and an inducible nuclear component. Proteins belonging to this family of transcription factors play a central role in inducible gene transcription during immune response. The product of this gene is an inducible nuclear component. It functions as a major molecular target for the immunosuppressive drugs such as ciclosporin. Five transcript variants encoding distinct isoforms have been identified for this gene. Different isoforms of this protein may regulate inducible expression of different cytokine genes.

Interactions

NFATC1 has been shown to interact with PIM1.

See also

• NFAT

Further reading

• Rao A, Luo C, Hogan PG (1997). "Transcription factors of the NFAT family: regulation and function". Annual Review of Immunology. 15: 707–47. doi:10.1146/annurev.immunol.15.1.707. PMID 9143705.
• Crabtree GR (Mar 1999). "Generic signals and specific outcomes: signaling through Ca2+, calcineurin, and NF-AT". Cell. 96 (5): 611–4. doi:10.1016/S0092-8674(00)80571-1. PMID 10089876. S2CID 8817053.
• Horsley V, Pavlath GK (Mar 2002). "NFAT: ubiquitous regulator of cell differentiation and adaptation". The Journal of Cell Biology. 156 (5): 771–4. doi:10.1083/jcb.200111073. PMC 2173310. PMID 11877454.
• Tolstrup M, Ostergaard L, Laursen AL, Pedersen SF, Duch M (Apr 2004). "HIV/SIV escape from immune surveillance: focus on Nef". Current HIV Research. 2 (2): 141–51. doi:10.2174/1570162043484924. PMID 15078178.
• Li X, Ho SN, Luna J, Giacalone J, Thomas DJ, Timmerman LA, Crabtree GR, Francke U (1995). "Cloning and chromosomal localization of the human and murine genes for the T-cell transcription factors NFATc and NFATp". Cytogenetics and Cell Genetics. 68 (3–4): 185–91. doi:10.1159/000133910. PMID 7842733.
• Jabado N, Le Deist F, Fisher A, Hivroz C (Nov 1994). "Interaction of HIV gp120 and anti-CD4 antibodies with the CD4 molecule on human CD4+ T cells inhibits the binding activity of NF-AT, NF-kappa B and AP-1, three nuclear factors regulating interleukin-2 gene enhancer activity". European Journal of Immunology. 24 (11): 2646–52. doi:10.1002/eji.1830241112. PMID 7957556. S2CID 30435577.
• Vacca A, Farina M, Maroder M, Alesse E, Screpanti I, Frati L, Gulino A (Nov 1994). "Human immunodeficiency virus type-1 tat enhances interleukin-2 promoter activity through synergism with phorbol ester and calcium-mediated activation of the NF-AT cis-regulatory motif". Biochemical and Biophysical Research Communications. 205 (1): 467–74. doi:10.1006/bbrc.1994.2689. PMID 7999066.
• Park J, Takeuchi A, Sharma S (Aug 1996). "Characterization of a new isoform of the NFAT (nuclear factor of activated T cells) gene family member NFATc". The Journal of Biological Chemistry. 271 (34): 20914–21. doi:10.1074/jbc.271.34.20914. PMID 8702849.
• Di Somma MM, Majolini MB, Burastero SE, Telford JL, Baldari CT (Sep 1996). "Cyclosporin A sensitivity of the HIV-1 long terminal repeat identifies distinct p56lck-dependent pathways activated by CD4 triggering". European Journal of Immunology. 26 (9): 2181–8. doi:10.1002/eji.1830260933. PMID 8814265. S2CID 23430217.
• Beals CR, Sheridan CM, Turck CW, Gardner P, Crabtree GR (Mar 1997). "Nuclear export of NF-ATc enhanced by glycogen synthase kinase-3". Science. 275 (5308): 1930–4. doi:10.1126/science.275.5308.1930. PMID 9072970. S2CID 22590899.
• Kinoshita S, Su L, Amano M, Timmerman LA, Kaneshima H, Nolan GP (Mar 1997). "The T cell activation factor NF-ATc positively regulates HIV-1 replication and gene expression in T cells". Immunity. 6 (3): 235–44. doi:10.1016/S1074-7613(00)80326-X. PMID 9075924.
• Zhou P, Sun LJ, Dötsch V, Wagner G, Verdine GL (Mar 1998). "Solution structure of the core NFATC1/DNA complex". Cell. 92 (5): 687–96. doi:10.1016/S0092-8674(00)81136-8. PMID 9506523. S2CID 16009648.
• Kinoshita S, Chen BK, Kaneshima H, Nolan GP (Nov 1998). "Host control of HIV-1 parasitism in T cells by the nuclear factor of activated T cells". Cell. 95 (5): 595–604. doi:10.1016/S0092-8674(00)81630-X. PMID 9845362. S2CID 17954556.
• Chuvpilo S, Zimmer M, Kerstan A, Glöckner J, Avots A, Escher C, Fischer C, Inashkina I, Jankevics E, Berberich-Siebelt F, Schmitt E, Serfling E (Feb 1999). "Alternative polyadenylation events contribute to the induction of NF-ATc in effector T cells". Immunity. 10 (2): 261–9. doi:10.1016/S1074-7613(00)80026-6. PMID 10072078.
• Chuvpilo S, Avots A, Berberich-Siebelt F, Glöckner J, Fischer C, Kerstan A, Escher C, Inashkina I, Hlubek F, Jankevics E, Brabletz T, Serfling E (Jun 1999). "Multiple NF-ATc isoforms with individual transcriptional properties are synthesized in T lymphocytes". Journal of Immunology. 162 (12): 7294–301. doi:10.4049/jimmunol.162.12.7294. PMID 10358178. S2CID 26133892.
• Wang JK, Kiyokawa E, Verdin E, Trono D (Jan 2000). "The Nef protein of HIV-1 associates with rafts and primes T cells for activation". Proceedings of the National Academy of Sciences of the United States of America. 97 (1): 394–9. Bibcode:2000PNAS...97..394W. doi:10.1073/pnas.97.1.394. PMC 26674. PMID 10618429.
• Porter CM, Havens MA, Clipstone NA (Feb 2000). "Identification of amino acid residues and protein kinases involved in the regulation of NFATc subcellular localization". The Journal of Biological Chemistry. 275 (5): 3543–51. doi:10.1074/jbc.275.5.3543. PMID 10652349.

External links

• NFATC1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.