NAB2

NGFI-A-binding protein 2 also known as EGR-1-binding protein 2 or melanoma-associated delayed early response protein (MADER) is a protein that in humans is encoded by the NAB2 gene.

NAB2
Identifiers
Aliases	NAB2, MADER, NGFI-A binding protein 2
External IDs	OMIM: 602381; MGI: 107563; HomoloGene: 4353; GeneCards: NAB2; OMA:NAB2 - orthologs
Gene location (Human) Chr. Chromosome 12 (human) Band 12q13.3 Start 57,089,043 bp End 57,095,476 bp
Gene location (Mouse) Chr. Chromosome 10 (mouse) Band 10 D3|10 74.6 cM Start 127,496,787 bp End 127,504,437 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right hemisphere of cerebellum left ovary right ovary popliteal artery canal of the cervix tibial arteries left uterine tube Descending thoracic aorta body of uterus anterior pituitary Top expressed in cerebellar vermis lobe of cerebellum lip calvaria external carotid artery internal carotid artery Gonadal ridge superior frontal gyrus olfactory tubercle dentate gyrus of hippocampal formation granule cell More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transcription factor binding protein binding transcription corepressor activity identical protein binding transcription coregulator activity Cellular component nucleus Biological process Schwann cell differentiation myelination negative regulation of transcription by RNA polymerase III cell population proliferation negative regulation of transcription, DNA-templated regulation of transcription, DNA-templated endochondral ossification regulation of epidermis development transcription, DNA-templated nervous system development positive regulation of tau-protein kinase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4665 17937 Ensembl ENSG00000166886 ENSMUSG00000025402 UniProt Q15742 Q61127 RefSeq (mRNA) NM_005967 NM_001330305 NM_001122895 NM_008668 RefSeq (protein) NP_001317234 NP_005958 NP_001116367 NP_032694 Location (UCSC) Chr 12: 57.09 – 57.1 Mb Chr 10: 127.5 – 127.5 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene encodes a member of the family of NGFI-A binding (NAB) proteins, which function in the nucleus to repress or activate transcription induced by some members of the EGR (early growth response) family of transactivators. NAB proteins can homo- or hetero-multimerize with other EGR or NAB proteins through a conserved N-terminal domain, and repress transcription through two partially redundant C-terminal domains. Transcriptional repression by the encoded protein is mediated in part by interactions with the nucleosome remodeling and deactylase (NuRD) complex. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.

Pathology

Recurrent somatic fusions of the two genes, NGFI-A–binding protein 2 (NAB2) and STAT6, located at chromosomal region 12q13, have been identified in solitary fibrous tumors.

Further reading

• Svaren J, Apel ED, Simburger KS, et al. (1997). "The Nab2 and Stat6 genes share a common transcription termination region". Genomics. 41 (1): 33–9. doi:10.1006/geno.1997.4609. PMID 9126479.
• Qu Z, Wolfraim LA, Svaren J, et al. (1998). "The transcriptional corepressor NAB2 inhibits NGF-induced differentiation of PC12 cells". J. Cell Biol. 142 (4): 1075–82. doi:10.1083/jcb.142.4.1075. PMC 2132876. PMID 9722618.
• Svaren J, Sevetson BR, Golda T, et al. (1998). "Novel mutants of NAB corepressors enhance activation by Egr transactivators". EMBO J. 17 (20): 6010–9. doi:10.1093/emboj/17.20.6010. PMC 1170927. PMID 9774344.
• Abdulkadir SA, Qu Z, Garabedian E, et al. (2001). "Impaired prostate tumorigenesis in Egr1-deficient mice". Nat. Med. 7 (1): 101–7. doi:10.1038/83231. PMID 11135623. S2CID 7191051.
• Abdulkadir SA, Carbone JM, Naughton CK, et al. (2001). "Frequent and early loss of the EGR1 corepressor NAB2 in human prostate carcinoma". Hum. Pathol. 32 (9): 935–9. doi:10.1053/hupa.2001.27102. PMID 11567222.
• Venken K, Di Maria E, Bellone E, et al. (2003). "Search for mutations in the EGR2 corepressor proteins, NAB1 and NAB2, in human peripheral neuropathies". Neurogenetics. 4 (1): 37–41. doi:10.1007/s10048-001-0124-2. PMID 12030330. S2CID 1928229.
• Lucerna M, Mechtcheriakova D, Kadl A, et al. (2003). "NAB2, a corepressor of EGR-1, inhibits vascular endothelial growth factor-mediated gene induction and angiogenic responses of endothelial cells". J. Biol. Chem. 278 (13): 11433–40. doi:10.1074/jbc.M204937200. PMID 12427750.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Kumbrink J, Gerlinger M, Johnson JP (2005). "Egr-1 induces the expression of its corepressor nab2 by activation of the nab2 promoter thereby establishing a negative feedback loop". J. Biol. Chem. 280 (52): 42785–93. doi:10.1074/jbc.M511079200. PMID 16260776.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Srinivasan R, Mager GM, Ward RM, et al. (2006). "NAB2 represses transcription by interacting with the CHD4 subunit of the nucleosome remodeling and deacetylase (NuRD) complex". J. Biol. Chem. 281 (22): 15129–37. doi:10.1074/jbc.M600775200. PMID 16574654.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.