NOLA2

H/ACA ribonucleoprotein complex subunit 2 is a protein that in humans is encoded by the NHP2 gene.

NHP2
Identifiers
Aliases	NHP2, DKCB2, NHP2P, NOLA2, NHP2 ribonucleoprotein
External IDs	OMIM: 606470; MGI: 1098547; HomoloGene: 5524; GeneCards: NHP2; OMA:NHP2 - orthologs
Gene location (Human) Chr. Chromosome 5 (human) Band 5q35.3 Start 178,149,463 bp End 178,153,894 bp
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band 11 B1.3|11 31.14 cM Start 51,510,562 bp End 51,514,541 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gums gingival epithelium oral cavity prefrontal cortex nucleus accumbens caudate nucleus putamen skin of leg ganglionic eminence skin of abdomen Top expressed in primitive streak hair follicle morula morula endothelial cell of lymphatic vessel yolk sac embryo epiblast embryo somite More reference expression data BioGPS More reference expression data
Gene ontology Molecular function box H/ACA snoRNA binding protein binding telomerase RNA binding snoRNA binding RNA binding Cellular component sno(s)RNA-containing ribonucleoprotein complex Cajal body box H/ACA telomerase RNP complex box H/ACA scaRNP complex nucleolus telomerase holoenzyme complex box H/ACA snoRNP complex nucleus cytosolic large ribosomal subunit nucleoplasm Biological process telomere maintenance via telomerase ribosome biogenesis positive regulation of telomerase RNA localization to Cajal body rRNA processing cleavage involved in rRNA processing snRNA pseudouridine synthesis maturation of LSU-rRNA protein biosynthesis rRNA pseudouridine synthesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55651 52530 Ensembl ENSG00000145912 ENSMUSG00000001056 UniProt Q9NX24 Q9CRB2 RefSeq (mRNA) NM_017838 NM_001034833 NM_001396110 NM_026631 NM_001364736 RefSeq (protein) NP_001030005 NP_060308 NP_080907 NP_001351665 Location (UCSC) Chr 5: 178.15 – 178.15 Mb Chr 11: 51.51 – 51.51 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

This gene is a member of the H/ACA snoRNPs (small nucleolar ribonucleoproteins) gene family. snoRNPs are involved in various aspects of rRNA processing and modification and have been classified into two families: C/D and H/ACA.

The H/ACA snoRNPs also include the DKC1, NOLA1 and NOLA3 proteins. These four H/ACA snoRNP proteins localize to the dense fibrillar components of nucleoli and coiled (Cajal) bodies in the nucleus. Both 18S rRNA production and rRNA pseudouridylation are impaired if any of the four proteins is depleted. The four H/ACA snoRNP proteins are also components of the telomerase complex. This gene encodes a protein related to Saccharomyces cerevisiae Nhp2p. Two transcript variants encoding different isoforms have been found for this gene.

Further reading

• Henras A, Henry Y, Bousquet-Antonelli C, et al. (1999). "Nhp2p and Nop10p are essential for the function of H/ACA snoRNPs". EMBO J. 17 (23): 7078–90. doi:10.1093/emboj/17.23.7078. PMC 1171055. PMID 9843512.
• Sanger Centre T, Washington University Genome Sequencing Cente T (1999). "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. doi:10.1101/gr.8.11.1097. PMID 9847074.
• Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
• Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. Bibcode:2002CBio...12....1A. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298. S2CID 14132033.
• Kang HS, Jung HM, Jun DY, et al. (2002). "Expression of the human homologue of the small nucleolar RNA-binding protein NHP2 gene during monocytic differentiation of U937 cells". Biochim. Biophys. Acta. 1575 (1–3): 31–9. doi:10.1016/s0167-4781(02)00240-3. PMID 12020816.
• Scherl A, Couté Y, Déon C, et al. (2003). "Functional proteomic analysis of human nucleolus". Mol. Biol. Cell. 13 (11): 4100–9. doi:10.1091/mbc.E02-05-0271. PMC 133617. PMID 12429849.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Wang C, Meier UT (2005). "Architecture and assembly of mammalian H/ACA small nucleolar and telomerase ribonucleoproteins". EMBO J. 23 (8): 1857–67. doi:10.1038/sj.emboj.7600181. PMC 394235. PMID 15044956.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.
• Slizhikova DK, Vinogradova TV, Sverdlov ED (2005). "[The NOLA2 and RPS3A genes as highly informative markers for human squamous cell lung cancer]". Bioorg. Khim. 31 (2): 195–9. doi:10.1007/s11171-005-0024-6. PMID 15889794. S2CID 21342977.