Nucleolar phosphoprotein p130

Nucleolar phosphoprotein p130 is a protein that in humans is encoded by the NOLC1 gene.

NOLC1
Identifiers
Aliases	NOLC1, NOPP130, NOPP140, NS5ATP13, P130, Nucleolar phosphoprotein p130, nucleolar and coiled-body phosphoprotein 1, Srp40
External IDs	OMIM: 602394; MGI: 1918019; HomoloGene: 68818; GeneCards: NOLC1; OMA:NOLC1 - orthologs
Gene location (Human) Chr. Chromosome 10 (human) Band 10q24.32 Start 102,152,176 bp End 102,163,871 bp
Gene location (Mouse) Chr. Chromosome 19 (mouse) Band 19|19 C3 Start 46,064,302 bp End 46,073,969 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in middle temporal gyrus Brodmann area 23 germinal epithelium parietal pleura gingival epithelium epithelium of nasopharynx endothelial cell pancreatic epithelial cell visceral pleura sperm Top expressed in morula epiblast primitive streak tail of embryo somite embryo yolk sac embryo mandibular prominence maxillary prominence More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding GTP binding protein binding ATP binding RNA binding RNA polymerase I core binding protein heterodimerization activity DNA binding DNA-binding transcription factor activity transcription factor binding nuclear localization sequence binding protein domain specific binding box C/D RNA binding box H/ACA snoRNA binding box C/D snoRNP complex binding box H/ACA snoRNP complex binding Cellular component cytoplasm Cajal body nucleus nucleoplasm nucleolus fibrillar center box C/D RNP complex box H/ACA snoRNP complex Biological process rRNA processing cell cycle nucleolus organization regulation of translation neural crest formation neural crest cell development mitotic cell cycle response to osmotic stress positive regulation of cell population proliferation box H/ACA RNA metabolic process regulation of protein import into nucleus positive regulation of transcription, DNA-templated Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9221 70769 Ensembl ENSG00000166197 ENSMUSG00000015176 UniProt Q14978 E9Q5C9 RefSeq (mRNA) NM_001284388 NM_001284389 NM_004741 NM_001039351 NM_001039352 NM_001039353 NM_053086 RefSeq (protein) NP_001271317 NP_001271318 NP_004732 NP_001034440 NP_001034441 NP_001034442 NP_444316 Location (UCSC) Chr 10: 102.15 – 102.16 Mb Chr 19: 46.06 – 46.07 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Interactions

Nucleolar phosphoprotein p130 has been shown to interact with coilin and CEBPB.

Further reading

• Nomura N, Miyajima N, Sazuka T, et al. (1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1". DNA Res. 1 (1): 27–35. doi:10.1093/dnares/1.1.27. PMID 7584026.
• Nomura N, Miyajima N, Sazuka T, et al. (1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 (supplement)". DNA Res. 1 (1): 47–56. doi:10.1093/dnares/1.1.47. PMID 7584028.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Pai CY, Yeh NH (1996). "Cell proliferation-dependent expression of two isoforms of the nucleolar phosphoprotein p130". Biochem. Biophys. Res. Commun. 221 (3): 581–7. doi:10.1006/bbrc.1996.0639. PMID 8630004.
• Miau LH, Chang CJ, Tsai WH, Lee SC (1997). "Identification and characterization of a nucleolar phosphoprotein, Nopp140, as a transcription factor". Mol. Cell. Biol. 17 (1): 230–9. doi:10.1128/MCB.17.1.230. PMC 231747. PMID 8972203.
• Li D, Meier UT, Dobrowolska G, Krebs EG (1997). "Specific interaction between casein kinase 2 and the nucleolar protein Nopp140". J. Biol. Chem. 272 (6): 3773–9. doi:10.1074/jbc.272.6.3773. PMID 9013635.
• Chen HK, Yeh NH (1997). "The nucleolar phosphoprotein P130 is a GTPase/ATPase with intrinsic property to form large complexes triggered by F- and Mg2+". Biochem. Biophys. Res. Commun. 230 (2): 370–5. doi:10.1006/bbrc.1996.5966. PMID 9016786.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Miau LH, Chang CJ, Shen BJ, et al. (1998). "Identification of heterogeneous nuclear ribonucleoprotein K (hnRNP K) as a repressor of C/EBPbeta-mediated gene activation". J. Biol. Chem. 273 (17): 10784–91. doi:10.1074/jbc.273.17.10784. PMID 9553145.
• Isaac C, Yang Y, Meier UT (1998). "Nopp140 functions as a molecular link between the nucleolus and the coiled bodies". J. Cell Biol. 142 (2): 319–29. doi:10.1083/jcb.142.2.319. PMC 2133063. PMID 9679133.
• Blanchette P, Gilchrist CA, Baker RT, Gray DA (2001). "Association of UNP, a ubiquitin-specific protease, with the pocket proteins pRb, p107 and p130". Oncogene. 20 (39): 5533–7. doi:10.1038/sj.onc.1204823. PMID 11571651.
• Chiu CM, Tsay YG, Chang CJ, Lee SC (2002). "Nopp140 is a mediator of the protein kinase A signaling pathway that activates the acute phase response alpha1-acid glycoprotein gene". J. Biol. Chem. 277 (42): 39102–11. doi:10.1074/jbc.M205915200. PMID 12167624.
• Wang C, Query CC, Meier UT (2003). "Immunopurified small nucleolar ribonucleoprotein particles pseudouridylate rRNA independently of their association with phosphorylated Nopp140". Mol. Cell. Biol. 22 (24): 8457–66. doi:10.1128/MCB.22.24.8457-8466.2002. PMC 139890. PMID 12446766.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Brill LM, Salomon AR, Ficarro SB, et al. (2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry". Anal. Chem. 76 (10): 2763–72. doi:10.1021/ac035352d. PMID 15144186.
• Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.