Neuropeptide FF receptor 2

Neuropeptide FF receptor 2, also known as NPFF2 is a human protein encoded by the NPFFR2 gene.

NPFFR2
Identifiers
Aliases	NPFFR2, GPR74, HLWAR77, NPFF2, NPGPR, neuropeptide FF receptor 2
External IDs	OMIM: 607449; MGI: 1860130; HomoloGene: 56982; GeneCards: NPFFR2; OMA:NPFFR2 - orthologs
Gene location (Human) Chr. Chromosome 4 (human) Band 4q13.3 Start 72,031,902 bp End 72,148,305 bp
Gene location (Mouse) Chr. Chromosome 5 (mouse) Band 5|5 E1 Start 89,675,288 bp End 89,731,599 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gonad testicle placenta islet of Langerhans prefrontal cortex parietal pleura gastric mucosa seminal vesicula Brodmann area 9 appendix Top expressed in primary oocyte zygote secondary oocyte embryo spinal ganglia blastocyst olfactory bulb mandibular prominence testicle trigeminal ganglion More reference expression data BioGPS n/a
Gene ontology Molecular function opioid receptor binding peptide binding G protein-coupled receptor activity signal transducer activity neuropeptide receptor activity Cellular component integral component of membrane plasma membrane integral component of plasma membrane membrane actin cytoskeleton Biological process G protein-coupled receptor signaling pathway detection of abiotic stimulus cellular response to hormone stimulus regulation of MAPK cascade regulation of adenylate cyclase activity regulation of cAMP-dependent protein kinase activity signal transduction response to peptide neuropeptide signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10886 104443 Ensembl ENSG00000056291 ENSMUSG00000035528 UniProt Q9Y5X5 Q924H0 RefSeq (mRNA) NM_001144756 NM_004885 NM_053036 NM_133192 RefSeq (protein) NP_001138228 NP_004876 NP_444264 NP_573455 Location (UCSC) Chr 4: 72.03 – 72.15 Mb Chr 5: 89.68 – 89.73 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

See also

• Neuropeptide FF receptor

Further reading

• Cikos S, Gregor P, Koppel J (1999). "Sequence and tissue distribution of a novel G-protein-coupled receptor expressed prominently in human placenta". Biochem. Biophys. Res. Commun. 256 (2): 352–6. doi:10.1006/bbrc.1999.0332. PMID 10079187.
• Parker RM, Copeland NG, Eyre HJ, et al. (2000). "Molecular cloning and characterisation of GPR74 a novel G-protein coupled receptor closest related to the Y-receptor family". Brain Res. Mol. Brain Res. 77 (2): 199–208. doi:10.1016/S0169-328X(00)00052-8. PMID 10837915.
• Elshourbagy NA, Ames RS, Fitzgerald LR, et al. (2000). "Receptor for the pain modulatory neuropeptides FF and AF is an orphan G protein-coupled receptor". J. Biol. Chem. 275 (34): 25965–71. doi:10.1074/jbc.M004515200. PMID 10851242.
• Bonini JA, Jones KA, Adham N, et al. (2001). "Identification and characterization of two G protein-coupled receptors for neuropeptide FF". J. Biol. Chem. 275 (50): 39324–31. doi:10.1074/jbc.M004385200. PMID 11024015.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Laemmle B, Schindler M, Beilmann M, et al. (2003). "Characterization of the NPGP receptor and identification of a novel short mRNA isoform in human hypothalamus". Regul. Pept. 111 (1–3): 21–9. doi:10.1016/S0167-0115(02)00220-3. PMID 12609745. S2CID 24049458.
• Engström M, Wurster S, Savola JM, Panula P (2004). "Functional properties of Pfr(Tic)amide and BIBP3226 at human neuropeptide FF2 receptors". Peptides. 24 (12): 1947–54. doi:10.1016/j.peptides.2003.10.009. PMID 15127947. S2CID 3833336.
• Mollereau C, Mazarguil H, Zajac JM, Roumy M (2005). "Neuropeptide FF (NPFF) analogs functionally antagonize opioid activities in NPFF2 receptor-transfected SH-SY5Y neuroblastoma cells". Mol. Pharmacol. 67 (3): 965–75. doi:10.1124/mol.104.004614. PMID 15608144. S2CID 9919973.
• Ankö ML, Panula P (2006). "Regulation of endogenous human NPFF2 receptor by neuropeptide FF in SK-N-MC neuroblastoma cell line". J. Neurochem. 96 (2): 573–84. doi:10.1111/j.1471-4159.2005.03581.x. PMID 16336216. S2CID 26460239.
• Ankö ML, Ostergård M, Lintunen M, Panula P (2007). "Alternative splicing of human and mouse NPFF2 receptor genes: Implications to receptor expression". FEBS Lett. 580 (30): 6955–60. doi:10.1016/j.febslet.2006.11.063. PMID 17157836. S2CID 29801987.
• Dahlman I, Dicker A, Jiao H, et al. (2007). "A common haplotype in the G-protein-coupled receptor gene GPR74 is associated with leanness and increased lipolysis". Am. J. Hum. Genet. 80 (6): 1115–24. doi:10.1086/518445. PMC 1867099. PMID 17503329.

External links

• "Neuropeptide FF Receptors: NPFF2". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2016-03-03. Retrieved 2008-12-09.