Nephrocalcin is an acidic glycoprotein, is produced by renal proximal tubule cells. It inhibits crystal nucleation, growth and aggregation.[1] It is one of the key inhibitors for Nephrolithiasis, kidney stone disease.[2]
References
edit- ^ Asplin, J.; DeGanello, S.; Nakagawa, Y. N.; Coe, F. L. (November 1991). "Evidence that nephrocalcin and urine inhibit nucleation of calcium oxalate monohydrate crystals". The American Journal of Physiology. 261 (5 Pt 2): F824–830. doi:10.1152/ajprenal.1991.261.5.F824. ISSN 0002-9513. PMID 1951713.
- ^ Negri, A. L.; Spivacow, F. R. (2023-03-25). "Kidney stone matrix proteins: Role in stone formation". World Journal of Nephrology. 12 (2): 21–28. doi:10.5527/wjn.v12.i2.21. PMC 10075018. PMID 37035509.