Nivacortol

Nivacortol
Clinical data
Other names	Nivazol; Nivazole; WIN-27914; Novozola; NEBO-174; 2'-(4-Fluorophenyl)-2'-H-pregna-2,4-dien-20-yno(3,2-c)pyrazol-17-ol
Drug class	Corticosteroid; Glucocorticoid
Identifiers
	IUPAC name (1R,3aS,3bR,10aR,10bS,12aS)-1-Ethynyl-7-(4-fluorophenyl)-10a,12a-dimethyl-1,2,3,3a,3b,4,5,7,10,10a,10b,11,12,12a-tetradecahydrocyclopenta[5,6]naphtho[1,2-f]indazol-1-ol;
CAS Number	24358-76-7;
PubChem CID	9910575;
ChemSpider	8086226;
UNII	50U0Z120RS;
KEGG	D05194;
ChEMBL	ChEMBL2106806;
CompTox Dashboard (EPA)	DTXSID301043242 ;
ECHA InfoCard	100.041.987
Chemical and physical data
Formula	C28H31FN2O
Molar mass	430.567 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@]2(C#C)O)CCC4=CC5=C(C[C@]34C)C=NN5C6=CC=C(C=C6)F;
	InChI InChI=InChI=1S/C28H31FN2O/c1-4-28(32)14-12-24-22-10-5-19-15-25-18(16-26(19,2)23(22)11-13-27(24,28)3)17-30-31(25)21-8-6-20(29)7-9-21/h1,6-9,15,17,22-24,32H,5,10-14,16H2,2-3H3/t22-,23+,24+,26+,27+,28+/m1/s1; Key:ZQLOAGFNRKBEAJ-BDPSOKNUSA-N;

Nivacortol (developmental code names WIN-27914 and NEBO-174; also known as nivazol and nivazole) is a synthetic glucocorticoid corticosteroid which was never marketed.^[1]^[2]^[3]^[4]

References

^ Elks J (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 881–882. ISBN 978-1-4757-2085-3.
^ "Nivazole". AdisInsight. Springer Nature Switzerland AG.
^ Elguero J, Silva AM, Tome AC (2011). "Five-Membered Heterocycles: 1,2-Azoles, Part 1. Pyrazoles". In Alvarez-Builla J, Vaquero JJ, Barluenga J (eds.). Modern Heterocyclic Chemistry. Vol. 1. John Wiley & Sons. pp. 649–. ISBN 978-3-527-33201-4.
^ Honour JW, Sudan HL, Lovell G (August 1986). "The determination of nivacortol in plasma using HPLC". Biomedical Chromatography. 1 (4): 151–154. doi:10.1002/bmc.1130010404. PMID 3506827.

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[Elks2014-1] Elks J (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 881–882. ISBN 978-1-4757-2085-3.

[AdisInsight-2] "Nivazole". AdisInsight. Springer Nature Switzerland AG.

[Alvarez-BuillaVaquero2011-3] Elguero J, Silva AM, Tome AC (2011). "Five-Membered Heterocycles: 1,2-Azoles, Part 1. Pyrazoles". In Alvarez-Builla J, Vaquero JJ, Barluenga J (eds.). Modern Heterocyclic Chemistry. Vol. 1. John Wiley & Sons. pp. 649–. ISBN 978-3-527-33201-4.

[pmid3506827-4] Honour JW, Sudan HL, Lovell G (August 1986). "The determination of nivacortol in plasma using HPLC". Biomedical Chromatography. 1 (4): 151–154. doi:10.1002/bmc.1130010404. PMID 3506827.

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