Nuclear pore complex protein Nup133

Nuclear pore complex protein Nup133, or Nucleoporin Nup133, is a protein that in humans is encoded by the NUP133 gene.

NUP133
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1XKS, 3CQC, 3CQG, 3I4R, 5A9Q
Identifiers
Aliases	NUP133, hnucleoporin 133kDa, nucleoporin 133, NPHS18, GAMOS8
External IDs	OMIM: 607613; MGI: 2442620; HomoloGene: 32402; GeneCards: NUP133; OMA:NUP133 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) Band 1q42.13 Start 229,440,259 bp End 229,508,341 bp
Gene location (Mouse) Chr. Chromosome 8 (mouse) Band 8|8 E2 Start 124,623,862 bp End 124,676,004 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte ventricular zone gonad parietal pleura tibia germinal epithelium visceral pleura palpebral conjunctiva epithelium of nasopharynx ganglionic eminence Top expressed in otic vesicle spermatocyte Gonadal ridge spermatid otic placode somite epiblast primitive streak mandibular prominence seminiferous tubule More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding structural constituent of nuclear pore Cellular component nucleus nuclear envelope chromosome chromosome, centromeric region kinetochore membrane cytosol outer kinetochore nuclear membrane nuclear pore nuclear pore outer ring host cell Biological process protein import into nucleus protein transport viral process neurogenesis neural tube development regulation of transcription, DNA-templated viral transcription mRNA transport regulation of cellular response to heat paraxial mesoderm development mitotic nuclear membrane disassembly nuclear pore organization protein sumoylation somite development intracellular transport of virus mRNA export from nucleus chromatin organization tRNA export from nucleus sister chromatid cohesion transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery regulation of gene silencing by miRNA regulation of glycolytic process transport nephron development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55746 234865 Ensembl ENSG00000069248 ENSMUSG00000039509 UniProt Q8WUM0 Q8R0G9 RefSeq (mRNA) NM_018230 NM_172288 RefSeq (protein) NP_060700 NP_758492 Location (UCSC) Chr 1: 229.44 – 229.51 Mb Chr 8: 124.62 – 124.68 Mb PubMed search
Wikidata
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Function

The nuclear envelope creates distinct nuclear and cytoplasmic compartments in eukaryotic cells. It consists of two concentric membranes perforated by nuclear pores, large protein complexes that form aqueous channels to regulate the flow of macromolecules between the nucleus and the cytoplasm. These complexes are composed of at least 100 different polypeptide subunits, many of which belong to the nucleoporin family. The nucleoporin protein encoded by this gene displays evolutionarily conserved interactions with other nucleoporins. This protein, which localizes to both sides of the nuclear pore complex at interphase, remains associated with the complex during mitosis and is targeted at early stages to the reforming nuclear envelope. This protein also localizes to kinetochores of mitotic cells.

Interactions

NUP133 has been shown to interact with NUP107.

Further reading

• Stoffler D, Fahrenkrog B, Aebi U (Jun 1999). "The nuclear pore complex: from molecular architecture to functional dynamics". Current Opinion in Cell Biology. 11 (3): 391–401. doi:10.1016/S0955-0674(99)80055-6. PMID 10395558.
• Bodoor K, Shaikh S, Enarson P, Chowdhury S, Salina D, Raharjo WH, Burke B (1999). "Function and assembly of nuclear pore complex proteins". Biochemistry and Cell Biology. 77 (4): 321–9. doi:10.1139/bcb-77-4-321. PMID 10546895.
• Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (Apr 1996). "A "double adaptor" method for improved shotgun library construction". Analytical Biochemistry. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
• Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (Apr 1997). "Large-scale concatenation cDNA sequencing". Genome Research. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
• Belgareh N, Rabut G, Baï SW, van Overbeek M, Beaudouin J, Daigle N, Zatsepina OV, Pasteau F, Labas V, Fromont-Racine M, Ellenberg J, Doye V (Sep 2001). "An evolutionarily conserved NPC subcomplex, which redistributes in part to kinetochores in mammalian cells". The Journal of Cell Biology. 154 (6): 1147–60. doi:10.1083/jcb.200101081. PMC 2150808. PMID 11564755.
• Walther TC, Alves A, Pickersgill H, Loïodice I, Hetzer M, Galy V, Hülsmann BB, Köcher T, Wilm M, Allen T, Mattaj IW, Doye V (Apr 2003). "The conserved Nup107-160 complex is critical for nuclear pore complex assembly". Cell. 113 (2): 195–206. doi:10.1016/S0092-8674(03)00235-6. PMID 12705868. S2CID 16449133.
• Loïodice I, Alves A, Rabut G, Van Overbeek M, Ellenberg J, Sibarita JB, Doye V (Jul 2004). "The entire Nup107-160 complex, including three new members, is targeted as one entity to kinetochores in mitosis". Molecular Biology of the Cell. 15 (7): 3333–44. doi:10.1091/mbc.E03-12-0878. PMC 452587. PMID 15146057.
• Berke IC, Boehmer T, Blobel G, Schwartz TU (Nov 2004). "Structural and functional analysis of Nup133 domains reveals modular building blocks of the nuclear pore complex". The Journal of Cell Biology. 167 (4): 591–7. doi:10.1083/jcb.200408109. PMC 2172596. PMID 15557116.
• Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R (Apr 2006). "Phosphoproteome analysis of the human mitotic spindle". Proceedings of the National Academy of Sciences of the United States of America. 103 (14): 5391–6. Bibcode:2006PNAS..103.5391N. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
• Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (Oct 2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nature Biotechnology. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (Nov 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
• Boehmer T, Schwartz TU (Sep 2007). "Purification, crystallization and preliminary X-ray analysis of a Nup107-Nup133 heterodimeric nucleoporin complex". Acta Crystallographica Section F. 63 (Pt 9): 816–8. doi:10.1107/S1744309107040523. PMC 2376328. PMID 17768364.